PTEN 抗体 (pSer380, pThr382, pThr383) (Biotin)
Quick Overview for PTEN 抗体 (pSer380, pThr382, pThr383) (Biotin) (ABIN6983019)
抗原
See all PTEN 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- pSer380, pThr382, pThr383
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Pig,Horse,Chicken
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated Synthesised phosphopeptide derived from human PTEN around the phosphorylation site of Ser380/Thr382/Thr383
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亚型
- IgG
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anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104), (N-Term) antibody
PTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB05082 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 69-104) antibodyPTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295), (C-Term) antibodyPTEN 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB5083 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 306-335) antibodyPTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 264-295) antibodyPTEN 适用: 人 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 363-392) antibodyPTEN 适用: 人 WB 宿主: 兔 Polyclonal RB39439 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 371-403) antibodyPTEN 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (AA 10-44), (N-Term) antibodyPTEN 适用: 人, 小鼠, 大鼠 WB 宿主: 小鼠 Monoclonal 1096CT4-3-3 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (pSer385) antibodyPTEN 适用: 人 DB 宿主: 兔 Polyclonal RB39440 unconjugated
anti-Phosphatase and Tensin Homolog (PTEN) (pTyr315) antibodyPTEN 适用: 人 DB 宿主: 兔 Polyclonal RB30516 unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- PTEN (Phosphatase and Tensin Homolog (PTEN))
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别名
- PTEN
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背景
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Synonyms: PTEN(Phospho-Ser380/Thr382/Thr383), PTEN(phospho S380/T382/Thr383), PTEN(Phospho-Ser380/Thr382/Thr383), ITGA 2, MGC11227, MHAM, MMAC 1, MMAC1, Bannayan Zonana, BZS a, Multiple hamartoma (Cowden syndrome), Mutated in Mutiple Advanced Cancers 1, Phosphatase and Tensin Homolog, Phosphatidylinositol 345 trisphosphate 3 phosphatase and dual specificity protein phosphatase PTEN, Phosphatidylinositol 345 trisphosphate 3 phosphatase, Platelet antigen BR, PTEN 1, PTEN1, Tensin homolog, TEP 1, TEP1, VLA 2 Receptor Alpha Subunit.
Background: Tumor suppressor. Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4. The lipid phosphatase activity is critical for its tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. The unphosphorylated form cooperates with AIP1 to suppress AKT1 activation. Dephosphorylates tyrosine-phosphorylated focal adhesion kinase and inhibits cell migration and integrin-mediated cell spreading and focal adhesion formation. Plays a role as a key modulator of the AKT-mTOR signaling pathway controlling the tempo of the process of newborn neurons integration during adult neurogenesis, including correct neuron positioning, dendritic development and synapse formation. May be a negative regulator of insulin signaling and glucose metabolism in adipose tissue. The nuclear monoubiquitinated form possesses greater apoptotic potential, whereas the cytoplasmic nonubiquitinated form induces less tumor suppressive ability.
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基因ID
- 5728
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UniProt
- P60484
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途径
- TCR Signaling, Fc-epsilon Receptor Signaling Pathway, EGFR Signaling Pathway, Inositol Metabolic Process, Synaptic Membrane, Regulation of Cell Size, Autophagy, Platelet-derived growth Factor Receptor Signaling, Signaling of Hepatocyte Growth Factor Receptor, BCR Signaling
抗原
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