CD163 抗体 (AA 551-650) (Biotin)
Quick Overview for CD163 抗体 (AA 551-650) (Biotin) (ABIN6982950)
抗原
See all CD163 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
 - AA 551-650
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交叉反应
 - 人, 小鼠
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预测反应
 - Rat
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纯化方法
 - Purified by Protein A.
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免疫原
 - KLH conjugated synthetic peptide derived from human CD163
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亚型
 - IgG
 
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应用备注
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                        WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 
                                            
限制
 - 仅限研究用
 
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状态
 - Liquid
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浓度
 - 1 μg/μL
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缓冲液
 - Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
 - ProClin
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注意事项
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
 - -20 °C
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储存方法
 - Store at -20°C for 12 months.
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有效期
 - 12 months
 
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- CD163
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别名
 - CD163
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背景
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Synonyms: Scavenger receptor cysteine-rich type 1 protein M130, CD 163, CD163 antigen, CD163 Molecule, Hemoglobin Scavenger Receptor, M130, M130 antigen precursor, Macrophage associated antigen, MM130, C163A_HUMAN.
Background: Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH -dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
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基因ID
 - 9332
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UniProt
 - Q86VB7
 
抗原
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