ABL2 抗体 (AA 581-680) (AbBy Fluor® 555)
Quick Overview for ABL2 抗体 (AA 581-680) (AbBy Fluor® 555) (ABIN6978757)
抗原
See all ABL2 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 581-680
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交叉反应
- 大鼠
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预测反应
- Human,Mouse,Dog
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human ABL2
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亚型
- IgG
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anti-ABL2 (ABL2) (AA 743-842) antibody
ABL2 适用: 人 WB, ELISA, PLA, RNAi 宿主: 小鼠 Monoclonal 6D5 unconjugated
anti-ABL2 (ABL2) (AA 743-842) antibodyABL2 适用: 人 WB, ELISA, IHC (p), IF 宿主: 小鼠 Monoclonal 5C6 unconjugated
anti-ABL2 (ABL2) antibodyABL2 适用: 人, 小鼠 ELISA, ICC 宿主: 小鼠 Monoclonal 1H1 unconjugated
anti-ABL2 (ABL2) antibodyABL2 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1H1B11 unconjugated
anti-ABL2 (ABL2) (pTyr393), (pTyr439) antibodyABL2 适用: 人 WB, IHC (p), DB 宿主: 兔 Polyclonal RB7532 unconjugated
anti-ABL2 (ABL2) antibodyABL2 适用: 人, 小鼠 WB, IHC (p) 宿主: 小鼠 Monoclonal 2C3 unconjugated
anti-ABL2 (ABL2) (AA 1011-1044), (C-Term) antibodyABL2 适用: 小鼠 WB 宿主: 兔 Polyclonal RB50829 unconjugated
anti-ABL2 (ABL2) (AA 862-1064) antibodyABL2 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-ABL2 (ABL2) (AA 1-1167) antibodyABL2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-ABL2 (ABL2) (Tyr251) antibodyABL2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
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应用备注
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IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
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有效期
- 12 months
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- ABL2
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别名
- ABL2
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背景
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Synonyms: Abelson murine leukemia viral oncogene homolog 2, Abelson related gene protein, Tyrosine kinase ARG, ABLL,ARG,Tyrosine protein kinase ABL2, v abl Abelson murine leukemia viral oncogene homolog 2, ABL2_HUMAN, Abelson tyrosine-protein kinase 2, Tyrosine-protein kinase ARG.
Background: Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement), CTTN (involved in signaling), or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1.
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基因ID
- 27
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UniProt
- P42684
抗原
-
