Ubinuclein 1 抗体 (AA 1-345)
Quick Overview for Ubinuclein 1 抗体 (AA 1-345) (ABIN6972900)
抗原
See all Ubinuclein 1 (UBN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 1-345
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产品特性
- UBN1 (Ubinuclein 1, also known as HIRA binding protein) is a ubiquitously expressed nuclear protein that acts as a novel regulator of senescence. UBN1 is involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. It is expressed in a number of cancer cell lines and tumors and may be required for replication-independent chromatin assembly. UBN1 is part of a large multi-subunit protein complex that interacts with CEBPA and Epstein-Barr virus BLZF1. It co-localizes with HIRA, PML and SP100 in the PML bodies of senescent cells. When overexpressed, UBN1 accumulates in the nucleus of cells defective for cytokinesis. Ubn1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
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纯化方法
- Affinity Purified
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免疫原
- This Ubinuclein antibody was raised against a recombinant protein corresponding to amino acids 1-345 of human Ubn1.
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亚型
- IgG
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anti-Ubinuclein 1 (UBN1) antibody
UBN1 适用: 人, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Ubinuclein 1 (UBN1) (Internal Region) antibodyUBN1 适用: 人, 小鼠 ELISA, WB 宿主: 兔 Polyclonal unconjugated
anti-Ubinuclein 1 (UBN1) (Internal Region) antibodyVerified UBN1 适用: 人 ELISA, WB 宿主: 山羊 Polyclonal unconjugated
anti-Ubinuclein 1 (UBN1) (AA 974-1023) antibodyUBN1 适用: 人, Cow, 犬, 豚鼠, 兔 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubinuclein 1 (UBN1) (AA 1-190) antibodyUBN1 适用: 人 WB, IP 宿主: 小鼠 Monoclonal UBN1-02 unconjugated
anti-Ubinuclein 1 (UBN1) (C-Term) antibodyUBN1 适用: 人, 小鼠, 大鼠, Cow, 犬 WB 宿主: 兔 Polyclonal unconjugated
anti-Ubinuclein 1 (UBN1) antibodyUBN1 适用: 人 DB 宿主: 小鼠 Monoclonal UBN1G12 unconjugated
anti-Ubinuclein 1 (UBN1) (AA 161-210) antibodyUBN1 适用: 人, 小鼠 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- Ubinuclein 1 (UBN1)
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别名
- Ubn1
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分子量
- 145 kDa
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NCBI登录号
- NP_001072982
抗原
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