SATB1 抗体 (N-Term)
Quick Overview for SATB1 抗体 (N-Term) (ABIN6972695)
抗原
See all SATB1 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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产品特性
- SATB1 (Special AT-rich sequence-binding protein 1) is a chromosome-associated protein that binds to matrix attachment regions (MARs) of DNA at special AT-rich sequences and induces local chromatin-loop remodeling. SATB1 functions as both a chromatin organizer and transcription factor. It regulates gene expression and higher-order chromatin structure of multigene clusters. SATB1 acts as a docking site for several chromatin remodeling enzymes and recruits corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. It is required for the switching of fetal globin genes, plays a role in chromatin organization and nuclear architecture during apoptosis. It is a crucial factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis. SATB1 contributes to metastatic potential in breast cancer cells, directly upregulating metastasis-associated genes while downregulating tumor-suppressor genes. It is also required for the differentiation of embryonic stem cells through repression of ES pluripotency factors Nanog, Klf4, and Tbx3. SATB1 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human and Mouse samples.
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纯化方法
- Affinity Purified
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免疫原
- This SATB1 antibody was raised against a peptide within the N-terminal region of SATB1.
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亚型
- IgG
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anti-SATB Homeobox 1 (SATB1) (AA 484-763) antibody
SATB1 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (C-Term) antibodySATB1 适用: 人, 小鼠, 大鼠, 兔, 豚鼠, 马 WB 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (AA 671-764) antibodySATB1 适用: 人, 小鼠 WB, ELISA, FACS, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (pSer47) antibodySATB1 适用: 人, 小鼠 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (AA 1-763) antibodySATB1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (Internal Region) antibodyVerified SATB1 适用: 人 WB, IHC, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) antibodySATB1 适用: 人 ICC, DB 宿主: 小鼠 Monoclonal 3548D4_2a unconjugated
anti-SATB Homeobox 1 (SATB1) antibodySATB1 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (AA 484-763) antibodySATB1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-SATB Homeobox 1 (SATB1) (AA 611-660) antibodySATB1 适用: 人, 大鼠, 兔, 豚鼠, 猴 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- SATB1 (SATB Homeobox 1 (SATB1))
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别名
- SATB1
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分子量
- 105 kDa
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NCBI登录号
- NP_001124482
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途径
- Caspase Cascade in Apoptosis, Activated T Cell Proliferation
抗原
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