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PKC beta 抗体 (C-Term)

Name: PKC beta 抗体 (C-Term)
Brand: antibodies-online
SKU: ABIN6972535
Availability: OutOfStock

This anti-PKC beta antibody is a 兔多克隆 antibody detecting PKC beta in WB. Suitable for 人.

PKC-B antibody (pAb) tested by Western blot. (PKC beta 抗体 (C-Term))

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产品编号 ABIN6972535

发货至: 中国

Quick Overview for PKC beta 抗体 (C-Term) (ABIN6972535)

抗原

See all PKC beta (PRKCB) 抗体

PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))

适用

人

宿主

兔

克隆类型

多克隆

标记

This PKC beta antibody is un-conjugated

应用范围

Western Blotting (WB)

Discover our top product PRKCB Primary Antibody

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C-Term

产品特性

PKC-B (Protein Kinase C, Beta) ia a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at Ser-180, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. PKC-B antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

纯化方法

Affinity Purified

免疫原

This antibody was raised against a peptide within the C-terminal region of human PKC-B.

亚型

IgG
anti-Protein Kinase C, beta (PRKCB) (AA 1-270) antibody
PRKCB 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 220-340) antibody
PRKCB 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (pThr500) antibody
PRKCB 适用: 人, 大鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 517-643) antibody
PRKCB 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (pThr641) antibody
PRKCB 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (Internal Region) antibody
Verified PRKCB 适用: 人, 大鼠 WB, ELISA, IHC 宿主: 山羊 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 642-673) antibody
PRKCB 适用: 人, 大鼠, 小鼠, 灵长类 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 601-673) antibody
PRKCB 适用: 人, 大鼠, 小鼠 WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 261-341) antibody
PRKCB 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

anti-Protein Kinase C, beta (PRKCB) (AA 1-671) antibody
PRKCB 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated

应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
缓冲液

Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
抗原

PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))

别名

PKC-B

分子量

85 kDa

NCBI登录号

NP_997700

途径

WNT signaling, TCR Signaling, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction, VEGF Signaling, Unfolded Protein Response, BCR Signaling