Menin 抗体 (C-Term)
Quick Overview for Menin 抗体 (C-Term) (ABIN6972340)
抗原
See all Menin (MEN1) 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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产品特性
- Menin (MEN1, SCG2) is a tumor suppressor and a component of multiple MLL-containing protein complexes (MLL, ACSOM, MLL2/3 and MLL3/4), which methylate histone H3 at lysine 4. Menin interacts directly with MLL through a domain in the N-terminus of MLL. It also interacts with RNA polymerase II large subunit C-terminal domain phosphorylated at Ser5. Menin is involved in the activation of HOX gene expression and is localized along with MLL at several HOX gene promoters. It is also important for activating the expression of several cell cycle regulators, indicating a mechanism for its role as a tumor suppressor. Defects in Menin are associated with inherited Multiple Endocrine Neoplasia type I, a dominant predisposition to cancer of a number of endocrine tissues. Menin antibody (pAb) was raised in a Rabbit host. It has been validated for use in Chromatin Immunoprecipitation, ChIP-Seq and Western blot, it has been shown to react with Human and Mouse samples.
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纯化方法
- Affinity Purified
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免疫原
- This Menin antibody was raised against a peptide corresponding to amino acids within the C-terminal region of human Menin.
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亚型
- IgG
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anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 392-554) antibody
MEN1 适用: 人 ELISA, IHC, FACS 宿主: 小鼠 Monoclonal 7D3E10 unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 501-615) antibodyMEN1 适用: 人, 小鼠, 大鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 219-395) antibodyMEN1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 1-575) antibodyMEN1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 1-575) antibodyMEN1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (Internal Region) antibodyMEN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 1-615) antibodyMEN1 适用: 人 ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (AA 506-615) antibodyMEN1 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) (Internal Region) antibodyMEN1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Multiple Endocrine Neoplasia 1 (MEN1) antibodyMEN1 适用: 人 WB 宿主: 兔 Monoclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- Menin (MEN1) (Multiple Endocrine Neoplasia 1 (MEN1))
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别名
- Menin
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分子量
- 80 kDa
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NCBI登录号
- NP_570716
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途径
- Chromatin Binding, Positive Regulation of Endopeptidase Activity
抗原
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