Histone H2A 抗体 (ubLys119)
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北京 101111
Quick Overview for Histone H2A 抗体 (ubLys119) (ABIN6971779)
抗原
See all Histone H2A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- ubLys119
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产品特性
- In humans, attachment of ubiquitin to Histone protein 2A (H2A) on lysine residue 119 (H2AK119Ub) is one of the most prevalent histone marks, and is estimated to occur on 5-15 % of histones genome-wide4. In general, H2AK119Ub is characteristic of repressed developmental genes, and is also tightly linked to levels of other histone marks such as lysine methylation and acetylation. H2AK119Ub is attached to histones by the Really Interesting New Gene (RING) ubiquitin E3-ligase Polycomb Repressive Complex 1 (PRC1), and removed by the Polycomb Repressive-Deubiquitinase (PR-DUB) complex, which plays a vital role in regulating H2AK119Ub histone marks, and mutations in human PR-DUB genes lead to a spectrum of malignancies. Histone H2AK119ub antibody (pAb) was raised in a Rabbit host. It has been validated for use in Dot blot and Western blot, it has been shown to react with Human samples, but it is predicted that it will react with a wide range of sample types.
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纯化方法
- Affinity Purified
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免疫原
- This antibody was raised against a branched peptide corresponding to the ubiquitin conjugation site at Lys119 of human Histone H2A.
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亚型
- IgG
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anti-Histone H2A (acLys5) antibody
适用: 人, 大鼠, 小鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (pSer139) antibody适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (H2AK95ac) antibody适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB6080 unconjugated Recombinant Antibody
anti-Histone H2A (acLys9) antibody适用: 人, 大鼠, 小鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (H2AK9ac) antibody适用: 人 ELISA, IF, ICC 宿主: 兔 Monoclonal 3H5 unconjugated Recombinant Antibody
anti-Histone H2A antibody适用: 人 WB, ELISA, IF 宿主: 兔 Monoclonal 1H12 unconjugated Recombinant Antibody
anti-Histone H2A (AA 1-128) antibody适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Histone H2A (H2AY39oh) antibody适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB6085 unconjugated Recombinant Antibody
anti-Histone H2A (H2AK118me1) antibody适用: 人 WB, FACS 宿主: 兔 Monoclonal 23GB6330 unconjugated Recombinant Antibody
anti-Histone H2A (pThr121) antibody适用: 人, 大鼠, 小鼠 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol, and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- Histone H2A
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分子量
- 23 kDa
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NCBI登录号
- NP_003508
抗原
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