DOT1L 抗体 (C-Term)
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北京 101111
Quick Overview for DOT1L 抗体 (C-Term) (ABIN6971602)
抗原
See all DOT1L 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- C-Term
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产品特性
- DOT1L (Disruptor of Telomeric silencing 1-like, also known as KMT4) is the mammalian homologue of the yeast Dot1 protein and the Drosophila Grappa protein. DOTL1 is the enzyme responsible for lysine 79 methylation of histone H3. DOT1L can promote an oncogenic pattern of gene expression through binding with several MLL fusion partners found in acute leukemia, thus leading to aberrant methylation of lysine 79 at MLL target genes. In contrast to most other histone lysine methyltransferases, DOT1L does not contain a SET domain. Biochemical studies suggest that recombinant DOT1L is active on recombinant nucleosomes. DOT1L antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
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纯化方法
- Affinity Purified
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免疫原
- This DOT1L antibody was raised against a peptide derived from the C-terminal region of human DOT1L.
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亚型
- IgG
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anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 3-108) antibody
DOT1L 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 6A6 unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 331-484) antibodyDOT1L 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 1390-1420), (C-Term) antibodyDOT1L 适用: 人 IHC (p) 宿主: 兔 Polyclonal RB2773 unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 51-150) antibodyDOT1L 适用: 人, 小鼠, 大鼠, Green Monkey WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro), ICC 宿主: 兔 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 1-250) antibodyDOT1L 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) antibodyDOT1L 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 3B6 unconjugated Recombinant Antibody
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 3-108) antibodyDOT1L 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (C-Term) antibodyDOT1L 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L) (AA 1390-1420) antibodyDOT1L 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- DOT1L (DOT1-Like, Histone H3 Methyltransferase (S. Cerevisiae) (DOT1L))
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别名
- DOT1L
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分子量
- 200 kDa
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NCBI登录号
- NP_115871
抗原
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