CDK9 抗体 (N-Term)
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北京 101111
Quick Overview for CDK9 抗体 (N-Term) (ABIN6971511)
抗原
See all CDK9 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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产品特性
- CDK9 (cyclin-dependent kinase 9) is a protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3, integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. CDK9 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
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纯化方法
- Affinity Purified
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免疫原
- This antibody was raised against a peptide within the N-terminal region of human CDK9.
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亚型
- IgG
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anti-Cyclin-Dependent Kinase 9 (CDK9) antibody
CDK9 适用: 人 WB, IHC, IP, IF, ChIP-seq 宿主: 兔 Monoclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 153-372) antibodyCDK9 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) antibodyCDK9 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 1B5A7 unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 153-372) antibodyCDK9 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (Internal Region) antibodyCDK9 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 271-372) antibodyCDK9 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D7 unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) antibodyCDK9 适用: 人 WB, ICC, FACS 宿主: 兔 Monoclonal 23GB1325 unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase 9 (CDK9) antibodyCDK9 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 104-315) antibodyCDK9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 153-372) antibodyCDK9 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- CDK9 (Cyclin-Dependent Kinase 9 (CDK9))
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别名
- CDK9
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分子量
- 44 kDa
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NCBI登录号
- NP_001252
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途径
- Cell Division Cycle
抗原
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