BAZ2A 抗体 (N-Term)
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北京 101111
Quick Overview for BAZ2A 抗体 (N-Term) (ABIN6971425)
抗原
See all BAZ2A 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- N-Term
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产品特性
- BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A) is an essential component of the NoRC (nucleolar remodeling complex) complex, a complex that mediates silencing of a fraction of rDNA by recruiting histone-modifying enzymes and DNA methyltransferases, leading to heterochromatin formation and transcriptional silencing. In the complex, it plays a central role by being recruited to rDNA and by targeting chromatin modifying enzymes such as HDAC1, leading to repress RNA polymerase I transcription. Recruited to rDNA via its interaction with TTF1 and its ability to recognize and bind histone H4 acetylated on 'Lys-16' (H4K16ac), leading to deacetylation of H4K5ac, H4K8ac, H4K12ac but not H4K16ac. Specifically binds pRNAs, 150-250 nucleotide RNAs that are complementary in sequence to the rDNA promoter, pRNA-binding is required for heterochromatin formation and rDNA silencing (By similarity). BAZ2A antibody (pAb) was raised in a Rabbit host. It has been validated for use in Immunofluorescence and Western blot, it has been shown to react with Human samples.
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纯化方法
- Affinity Purified
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免疫原
- This antibody was raised against a peptide within the N-terminal region of human BAZ2A.
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亚型
- IgG
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anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) antibody
BAZ2A 适用: 人 WB, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) (N-Term) antibodyBAZ2A 适用: 人 ELISA, WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) (AA 97-266) antibodyBAZ2A 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) (AA 1-1905) antibodyBAZ2A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A) antibodyBAZ2A 适用: 人 WB, ChIP 宿主: 兔 Polyclonal unconjugated
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应用备注
- Optimal working dilution should be determined by the investigator.
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限制
- 仅限研究用
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缓冲液
- Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
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- BAZ2A (Bromodomain Adjacent To Zinc Finger Domain, 2A (BAZ2A))
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别名
- BAZ2A
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分子量
- 270 kDa
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NCBI登录号
- NP_038477
抗原
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