IL-12/IL-23 p40 抗体
This anti-IL-12/IL-23 p40 antibody is a 大鼠 单克隆 antibody detecting IL-12/IL-23 p40 in FACS, ELISA, IF, IP, Func 和 WB. Suitable for 小鼠.
Quick Overview for IL-12/IL-23 p40 抗体 (ABIN6961468)
抗原
IL-12/IL-23 p40
适用
小鼠
宿主
大鼠
克隆类型
单克隆
标记
This IL-12/IL-23 p40 antibody is un-conjugated
应用范围
Flow Cytometry (FACS), ELISA, Immunofluorescence (IF), Immunoprecipitation (IP), Functional Studies (Func), Western Blotting (WB)
克隆位点
C17-8
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纯化方法
- This monoclonal antibody preparation was purified from tissue culture supernatant via affinity chromatography. For In Vivo Ready™ (IVR) products, each preparation is also evaluated for endotoxin levels using the LAL assay. It is recommended to store the product undiluted at 4°C. Do not freeze.
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内毒素水平
- Low endotoxin: < 0.01 EU/ug
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亚型
- IgG2a kappa
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anti-IL-12/IL-23 p40 antibody (APC)
适用: 小鼠 FACS 宿主: 大鼠 Monoclonal C17-8 APC
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应用备注
- This purified format is guaranteed to be >90 % pure as determined by SDS-PAGE analysis.
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说明
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2 mg/mL
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限制
- 仅限研究用
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缓冲液
- 10 mM NaH2PO4, 150 mM NaCl, pH 7.2
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储存液
- Azide free
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储存条件
- 4 °C
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储存方法
- 2-8°C
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有效期
- 12 months
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- IL-12/IL-23 p40
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背景
- The C17.8 antibody is specific for the 40 kDa (p40) protein subunit shared by the cytokines IL-12 and IL-23. To form IL-12, p40 assembles with a separate 35 kDa protein, known as p35, resulting in a 70 kDa functional cytokine. IL-12 is secreted by activated monocytes, mac- rophages, and dendritic cells, and has been shown to target naive, resting CD4+ T cells to promote their proliferation and secretion of cytokines. IL-23 contains the p40 subunit in combination with a 19 kDa protein chain, p19 - its primary source being activated dendritic cells and other antigen-presenting cells. IL-23 appears to target different cell types than IL-12, acting on memory CD4+ T cells to induce a strong proliferative response and contributing to the generation and expansion of Th17 cells. Like the cytokines themselves, the re- ceptors for IL-12 and IL-23 share one subunit, as well as containing distinct cytokine-specific subunits.As the C17.8 antibody binds to a shared subunit of both IL-12 and IL-23, it may be used as a marker for either IL-12 or IL-23 expression in dendritic cells, monocytes and macrophages, and is widely used for neutralization of activity associated with either cytokine.
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基因ID
- 16160
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UniProt
- P43432
抗原
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