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IL7R 抗体 (APC)

This anti-IL7R antibody is a 大鼠 单克隆 antibody detecting IL7R in FACS. Suitable for 小鼠.
产品编号 ABIN7278008
发货至: 中国

Quick Overview for IL7R 抗体 (APC) (ABIN7278008)

抗原

See all IL7R 抗体
IL7R (Interleukin 7 Receptor (IL7R))

适用

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小鼠

宿主

  • 89
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大鼠

克隆类型

  • 90
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  • 3
单克隆

标记

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This IL7R antibody is conjugated to APC

应用范围

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Flow Cytometry (FACS)

克隆位点

A7R34
  • 纯化方法

    This monoclonal antibody was purified from tissue culture supernatant via affinity chromatography. The purified antibody was conjugated under optimal conditions, with unreacted dye removed from the preparation. It is recommended to store the product undiluted at 4°C, and protected from prolonged exposure to light. Do not freeze.

    亚型

    IgG2a kappa
  • 应用备注

    This antibody preparation has been quality-tested for flow cytometry using mouse spleen cells, or an appropriate cell type (where indi- cated). The amount of antibody required for optimal staining of a cell sample should be determined empirically in your system.

    说明

    0.2 mg/mL

    限制

    仅限研究用
  • 缓冲液

    10 mM NaH2PO4, 150 mM NaCl, 0.09 % Sodium azide, 0.1 % gelatin, pH 7.2

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C

    储存方法

    2-8°C protected from light

    有效期

    12 months
  • 抗原

    IL7R (Interleukin 7 Receptor (IL7R))

    别名

    CD127 (IL-7Ra)

    背景

    The A7R34 antibody is specific for mouse CD127, a 60-90 kDa cell surface protein also known as the Interleukin-7 Receptor alpha chain, or IL-7R alpha. CD127 is typically expressed at the cell surface as a heterodimer with the common gamma chain (CD132). This complex acts as the functional receptor for IL-7, a cytokine important in T and B cell development, and in mature T cell homeostasis. A second cytokine known as Thymic Stromal Lymphopoietin (TSLP) also binds to a receptor complex of CD127 and the TSLPR chain to trigger activation of dendritic cells, and is involved in B cell development, allergy and autoimmunity.The A7R34 antibody may be used as a phenotypic marker for CD127 on immature B cells, on subsets of thymocytes which are double negative (CD4-CD8- ) or single positive (CD4+ or CD8+), and at low levels on mature, peripheral T cells. CD127 is a key marker, when used in combination with CD4 and CD25, to distinguish Treg and effector/memory Treg populations known as T(REM).

    基因ID

    16172

    UniProt

    P16872

    途径

    JAK/STAT Signaling, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Regulation of Cell Size
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