H2AFZ 抗体 (acLys4)
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北京 101111
Quick Overview for H2AFZ 抗体 (acLys4) (ABIN6952410)
抗原
See all H2AFZ 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- acLys4
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特异性
- Monoclonal antibody raised in rabbit against histone H2A.Z acetylated at Lys4 (H2A.ZK4ac), using a KLH-conjugated synthetic peptide.
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纯化方法
- Protein A purified
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免疫原
- synthetic peptide
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应用备注
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ChIP 0.5-1 μg:ChIP
WB 1:1,000
IF 1:500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- PBS, 50 % glycerol, 1 % BSA , 0.05 % azide
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- H2AFZ (H2A Histone Family, Member Z (H2AFZ))
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别名
- H2A.Z
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背景
- Histones are the main constituents of the protein part of chromosomes of eukaryotic cells. They are rich in the amino acids arginine and lysine and have been greatly conserved during evolution. Histones pack the DNA into tight masses of chromatin. Two core histones of each class H2A, H2B, H3 and H4 assemble and are wrapped by 146 base pairs of DNA to form one octameric nucleosome. Histone tails undergo numerous post-translational modifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression or other nuclear processes. In addition to the genetic code, combinations of the different histone modifications reveal the so-called "histone code". Histone methylation and demethylation is dynamically regulated by respectively histone methyl transferases and histone demethylases. Acetylation of H2A.ZK4 is associated with gene activation.
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UniProt
- P0C0S5
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途径
- Telomere Maintenance
抗原
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