HDAC1 抗体
Quick Overview for HDAC1 抗体 (ABIN6952380)
抗原
See all HDAC1 抗体适用
宿主
克隆类型
标记
应用范围
质量等级
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特异性
- Polyclonal antibody raised in rabbit against the C-terminal region of human HDAC1 (Histone deacetylase 1), using a KLH-conjugated synthetic peptide.
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交叉反应
- 小鼠
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纯化方法
- Peptide affinity purified
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免疫原
- synthetic peptide
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应用备注
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ChIP/ChIP-seq 2 μg:ChIP
ELISA 1:4,000
WB 1:1,000
Protein array 1:100,000
IF 1:500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1.73 μg/μL
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缓冲液
- PBS, 0.05 % azide, 0.05 % ProClin300
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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- HDAC1 (Histone Deacetylase 1 (HDAC1))
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别名
- HDAC1
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背景
- HDAC1 (UniProt/Swiss-Prot entry Q13547) catalyses the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Acetylation and deacetylation of these highly conserved lysine residues is important for the control of gene expression and HDAC activity is often associated with gene repression. Histone deacetylation is established by the formation of large multiprotein complexes. HDAC1 also interacts with the retinoblastoma tumor suppressor protein and is able to deacetylate p53. Therefore, it also plays an essential role in cell proliferation and differentiation and in apoptosis.
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UniProt
- Q13547
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途径
- Neurotrophin Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Mitotic G1-G1/S Phases, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development, Negative Regulation of intrinsic apoptotic Signaling, Embryonic Body Morphogenesis
抗原
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