COL2 抗体
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北京 101111
Quick Overview for COL2 抗体 (ABIN6950841)
抗原
See all COL2 抗体适用
宿主
克隆类型
标记
应用范围
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原理
- E-Cadherin mouse mAb
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特异性
- The antibody can specifically recognize E-cadherin protein.
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纯化方法
- The antibody was purified by affinity chromatography using a specific immunogen.
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免疫原
- A synthetic peptide corresponding to the amino acid region 700 - 800 of the human E - Cadherin protein.
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亚型
- IgG
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应用备注
- IHC, 1:200-1:400
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限制
- 仅限研究用
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状态
- Liquid
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缓冲液
- The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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注意事项
- Avoid freeze / thaw cycles
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储存条件
- -20 °C
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储存方法
- Store at-20°C. Avoid freeze / thaw cycles.
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- COL2 (Collagen, Type II (COL2))
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别名
- Collagen Type II
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背景
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Synonyms: Cadherin-1, CAM 120/80, Epithelial cadherin (E-cadherin) , Uvomorulin, CD324, CDH1, CDHE
Background: E-Cadherein, 120 kDa, is a critical regulator of epithelial junction formation. The E-cadherin internal domain binds with alpha, beta, gamma, and p120 catenins to anchor the ECAD complex to the actin cytoskeleton of the cell. E-cadherin is expressed in virtually all epithelial cells with the exception of adrenocortical cells. The expression in liver cells is weaker than in most other epithelia. ECAD is also expressed in melanocytes (adhering to squamous epithelial cells) . Mesothelial cells and granulosa cells are ECAD negative. Mesenchymal cells and neural crest cells are mostly negative but some types may show a weak reaction. Testicular germinative cells are weakly positive. At present, it is commonly used to differentiate breast lobular cancer from ductal cancer (the former is often negative, the latter is often positive) .
Gene Name: CDH1
Protein Name: E-Cadherin
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基因ID
- 999
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UniProt
- P12830
抗原
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