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COL2 抗体

The 小鼠 单克隆 anti-COL2 antibody is suitable to detect COL2 in samples from 人. It has been validated for IHC.
产品编号 ABIN6950841
发货至: 中国
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北京 101111
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Room 801-803
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Tel +86 (0512) 65829739 传真 +86 (010) 6788 5057

Quick Overview for COL2 抗体 (ABIN6950841)

抗原

See all COL2 抗体
COL2 (Collagen, Type II (COL2))

适用

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人

宿主

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小鼠

克隆类型

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单克隆

标记

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This COL2 antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC)
  • 原理

    E-Cadherin mouse mAb

    特异性

    The antibody can specifically recognize E-cadherin protein.

    纯化方法

    The antibody was purified by affinity chromatography using a specific immunogen.

    免疫原

    A synthetic peptide corresponding to the amino acid region 700 - 800 of the human E - Cadherin protein.

    亚型

    IgG
  • 应用备注

    IHC, 1:200-1:400

    限制

    仅限研究用
  • 状态

    Liquid

    缓冲液

    The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    注意事项

    Avoid freeze / thaw cycles

    储存条件

    -20 °C

    储存方法

    Store at-20°C. Avoid freeze / thaw cycles.
  • 抗原

    COL2 (Collagen, Type II (COL2))

    别名

    Collagen Type II

    背景

    Synonyms: Cadherin-1, CAM 120/80, Epithelial cadherin (E-cadherin) , Uvomorulin, CD324, CDH1, CDHE

    Background: E-Cadherein, 120 kDa, is a critical regulator of epithelial junction formation. The E-cadherin internal domain binds with alpha, beta, gamma, and p120 catenins to anchor the ECAD complex to the actin cytoskeleton of the cell. E-cadherin is expressed in virtually all epithelial cells with the exception of adrenocortical cells. The expression in liver cells is weaker than in most other epithelia. ECAD is also expressed in melanocytes (adhering to squamous epithelial cells) . Mesothelial cells and granulosa cells are ECAD negative. Mesenchymal cells and neural crest cells are mostly negative but some types may show a weak reaction. Testicular germinative cells are weakly positive. At present, it is commonly used to differentiate breast lobular cancer from ductal cancer (the former is often negative, the latter is often positive) .

    Gene Name: CDH1

    Protein Name: E-Cadherin

    基因ID

    999

    UniProt

    P12830
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