PRP19 抗体
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北京 101111
Quick Overview for PRP19 抗体 (ABIN6944680)
抗原
See all PRP19 (PRPF19) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Human PRP19 between 450-550 amino acids
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亚型
- IgG
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anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 127-416) antibody
PRPF19 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 1-90) antibodyPRPF19 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E5 unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 1-90) antibodyPRPF19 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) antibodyPRPF19 适用: 人 WB, IF, ICC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 4-33), (N-Term) antibodyPRPF19 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20845 unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (Middle Region) antibodyPRPF19 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 斑马鱼, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (N-Term) antibodyPRPF19 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 151-200) antibodyPRPF19 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 斑马鱼, Pig, 豚鼠, Bat, 猴, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) antibodyPRPF19 适用: 人, 小鼠, 大鼠, 犬, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (Internal Region) antibodyPRPF19 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC() -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))
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别名
- PRP19
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背景
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Synonyms: Pre-mRNA-processing factor 19, Nuclear matrix protein 200, PRP19/PSO4 homolog, Senescence evasion factor, hPso4, PRPF19
Background: Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity).
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基因ID
- 27339
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UniProt
- Q9UMS4
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途径
- Ribonucleoprotein Complex Subunit Organization
抗原
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