PRP19 抗体 (N-Term)
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- 抗原 See all PRP19 (PRPF19) 抗体
- PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))
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抗原表位
- N-Term
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PRP19 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- PRPF19 Antibody detects endogenous levels of total PRPF19.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Chicken
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human PRPF19, corresponding to a region within N-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product PRPF19 Primary Antibody
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anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 1-90) antibody
PRPF19 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E5 unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 127-416) antibodyPRPF19 适用: 人 WB, IHC, IP 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) antibodyPRPF19 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 1-90) antibodyPRPF19 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) antibodyPRPF19 适用: 人 WB, IHC (p), IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 4-33), (N-Term) antibodyPRPF19 适用: 人, 小鼠 WB, FACS, IHC (p) 宿主: 兔 Polyclonal RB20845 unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (Middle Region) antibodyPRPF19 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 斑马鱼, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (AA 151-200) antibodyPRPF19 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 兔, 斑马鱼, 豚鼠, Pig, Bat, 猴, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) (Internal Region) antibodyPRPF19 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Pre-mRNA Processing Factor 19 (PRPF19) antibodyPRPF19 适用: 人, 小鼠, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IHC 1:50-1:200, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- PRP19 (PRPF19) (Pre-mRNA Processing Factor 19 (PRPF19))
- 别名
- PRPF19 (PRPF19 产品)
- 别名
- NMP200 antibody, fb18f09 antibody, zgc:56158 antibody, wu:fb18f09 antibody, nmp200 antibody, PRP19 antibody, PSO4 antibody, SNEV antibody, UBOX4 antibody, hPSO4 antibody, Prp19 antibody, nmp-200 antibody, AA617263 antibody, AL024362 antibody, D19Wsu55e antibody, Snev antibody, pre-mRNA processing factor 19 antibody, pre-mRNA processing factor 19 L homeolog antibody, prpf19 antibody, prpf19.L antibody, PRPF19 antibody, Prpf19 antibody
- 背景
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Description: Ubiquitin-protein ligase which is a core component of several complexes mainly involved pre-mRNA splicing and DNA repair. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 component PRPF8 and stabilizes the U4/U5/U6 tri-snRNP spliceosomal complex (PubMed:20595234). Recruited to RNA polymerase II C-terminal domain (CTD) and the pre-mRNA, it may also couple the transcriptional and spliceosomal machineries (PubMed:21536736). The XAB2 complex, which contains PRPF19, is also involved in pre-mRNA splicing, transcription and transcription-coupled repair (PubMed:17981804). Beside its role in pre-mRNA splicing PRPF19, as part of the PRP19-CDC5L complex, plays a role in the DNA damage response/DDR. It is recruited to the sites of DNA damage by the RPA complex where PRPF19 directly ubiquitinates RPA1 and RPA2. 'Lys-63'-linked polyubiquitination of the RPA complex allows the recruitment of the ATR-ATRIP complex and the activation of ATR, a master regulator of the DNA damage response (PubMed:24332808). May also play a role in DNA double-strand break (DSB) repair by recruiting the repair factor SETMAR to altered DNA (PubMed:18263876). As part of the PSO4 complex may also be involved in the DNA interstrand cross-links/ICLs repair process (PubMed:16223718). In addition, may also mediate 'Lys-48'-linked polyubiquitination of substrates and play a role in proteasomal degradation (PubMed:11435423). May play a role in the biogenesis of lipid droplets (By similarity). May play a role in neural differentiation possibly through its function as part of the spliceosome (By similarity).
Gene: PRPF19
- 分子量
- 50 kDa
- 基因ID
- 27339
- UniProt
- Q9UMS4
- 途径
- Ribonucleoprotein Complex Subunit Organization
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