NONO 抗体
Quick Overview for NONO 抗体 (ABIN6944300)
抗原
See all NONO 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
交叉反应
- 人, 小鼠, 大鼠
-
纯化方法
- Purified by Protein A.
-
免疫原
- Recombinant protein of C-terminal human p54nrb.
-
亚型
- IgG
-
-
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (AA 184-385) antibody
NONO 适用: 人, 小鼠, 犬, 猴 WB, IHC, IF, IHC (p) 宿主: 小鼠 Monoclonal 3F8 unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (AA 184-385) antibodyNONO 适用: 人, 小鼠, 大鼠, 犬, 猴 WB, IHC, IHC (p) 宿主: 小鼠 Monoclonal 2E7 unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (AA 1-300) antibodyNONO 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (C-Term) antibodyNONO 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠, 兔 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) antibodyNONO 适用: 人 WB, IHC, IF, ELISA 宿主: 兔 Monoclonal 8C11 unconjugated Recombinant Antibody
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (N-Term) antibodyNONO 适用: 人 WB, IF, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (C-Term) antibodyNONO 适用: 人, 犬, 猴, 马, Cow, 豚鼠, 兔, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (C-Term) antibodyNONO 适用: 人, 犬 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (AA 1-35), (N-Term) antibodyNONO 适用: 人, 小鼠, 大鼠 WB, IHC, IF, ICC, FACS 宿主: 兔 Polyclonal unconjugated
anti-Non-POU Domain Containing, Octamer-Binding (NONO) (N-Term) antibodyNONO 适用: 人, 小鼠, 大鼠, 犬, 马, Cow, 豚鼠 WB, IF 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
-
-
-
状态
- Liquid
-
浓度
- 1 μg/μL
-
缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
-
储存液
- ProClin
-
注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
-
储存条件
- -20 °C
-
储存方法
- Store at -20°C for 12 months.
-
有效期
- 12 months
-
-
- NONO (Non-POU Domain Containing, Octamer-Binding (NONO))
-
别名
- NONO
-
背景
-
Synonyms: Non-POU domain-containing octamer-binding protein, 54 kDa nuclear RNA- and DNA-binding protein, 55 kDa nuclear protein, DNA-binding p52/p100 complex 52 kDa subunit, NMT55, p54(nrb), p54nrb, NONO, NRB54
Background: DNA- and RNA binding protein, involved in several nuclear processes. Binds the conventional octamer sequence in double stranded DNA. Also binds single-stranded DNA and RNA at a site independent of the duplex site. Involved in pre-mRNA splicing, probably as an heterodimer with SFPQ. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. The SFPQ-NONO heteromer may be involved in DNA unwinding by modulating the function of topoisomerase I/TOP1. The SFPQ-NONO heteromer may be involved in DNA nonhomologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination and may stabilize paired DNA ends. In vitro, the complex strongly stimulates DNA end joining, binds directly to the DNA substrates and cooperates with the Ku70/G22P1-Ku80/XRCC5 (Ku) dimer to establish a functional preligation complex. Nono is involved in transcriptional regulation. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. NONO binds to an enhancer element in long terminal repeats of endogenous intracisternal A particles (IAPs) and activates transcription.
-
基因ID
- 4841
-
UniProt
- Q15233
抗原
-
