STK3 抗体
Quick Overview for STK3 抗体 (ABIN6944127)
抗原
See all STK3 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Human Mst2 aa 1-100
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亚型
- IgG
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anti-serine/threonine Kinase 3 (STK3) (AA 323-450) antibody
STK3 适用: 人 WB, IHC, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 1-491) antibodySTK3 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 311-431) antibodySTK3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-serine/threonine Kinase 3 (STK3) (C-Term) antibodySTK3 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 兔, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) antibodySTK3 适用: 人 WB, IHC, IF 宿主: 兔 Monoclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) (N-Term) antibodySTK3 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 兔, 马, 豚鼠, Pig WB 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 396-425), (C-Term) antibodySTK3 适用: 人, 小鼠, 大鼠, 猴 WB, IHC (p) 宿主: 兔 Polyclonal RB1196 unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 253-350) antibodySTK3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 1-491) antibodySTK3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) antibodySTK3 适用: 人, 猴, 犬 WB, IHC 宿主: 小鼠 Monoclonal 4G10 unconjugated
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应用备注
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WB 1:300-5000
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- STK3 (serine/threonine Kinase 3 (STK3))
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别名
- Mst2
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背景
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Synonyms: Serine/threonine-protein kinase 3, Mammalian STE20-like protein kinase 2, STE20-like kinase MST2, Serine/threonine-protein kinase Krs-1, MST-2, STK3, KRS1, MST2
Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on 'Ser-259'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on 'Thr-74'. Acts cooperatively with MOBKL1B to activate STK38.
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基因ID
- 6788
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UniProt
- Q13188
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途径
- Tube Formation
抗原
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