STK3 抗体 (AA 323-450)
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- 抗原 See all STK3 抗体
- STK3 (serine/threonine Kinase 3 (STK3))
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抗原表位
- AA 323-450
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适用
- 人
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This STK3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF)
- 交叉反应
- 人, 小鼠
- 纯化方法
- Antigen Affinity Purified
- 免疫原
- Recombinant Human Serine/threonine-protein kinase 3 protein (323-450AA)
- 亚型
- IgG
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anti-serine/threonine Kinase 3 (STK3) antibody
STK3 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 1-491) antibodySTK3 适用: 人 WB, IF, PLA 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 311-431) antibodySTK3 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4F7 unconjugated
anti-serine/threonine Kinase 3 (STK3) (C-Term) antibodySTK3 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 兔, 马, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) (N-Term) antibodySTK3 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 兔, 马, Pig, 豚鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 396-425), (C-Term) antibodySTK3 适用: 人, 小鼠, 大鼠, 猴 WB, IHC (p) 宿主: 兔 Polyclonal RB1196 unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 1-491) antibodySTK3 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 253-350) antibodySTK3 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B3 unconjugated
anti-serine/threonine Kinase 3 (STK3) antibodySTK3 适用: 人, 犬, 猴 WB, IHC 宿主: 小鼠 Monoclonal 4G10 unconjugated
anti-serine/threonine Kinase 3 (STK3) (AA 351-400) antibodySTK3 适用: 人, 小鼠, 大鼠, Cow, 斑马鱼, 犬, 猴, 兔, 马, Pig, 豚鼠, Bat WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
- Recommended dilution: WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200,
- 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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- 抗原
- STK3 (serine/threonine Kinase 3 (STK3))
- 别名
- STK3 (STK3 产品)
- 别名
- KRS1 antibody, MST2 antibody, 0610042I06Rik antibody, MST antibody, Mst2 antibody, Mst3 antibody, Ste20 antibody, mess1 antibody, mst2 antibody, xstk3 antibody, wu:fc19e11 antibody, zgc:55383 antibody, serine/threonine kinase 3 antibody, serine/threonine kinase 3 S homeolog antibody, serine/threonine kinase 3 (STE20 homolog, yeast) antibody, STK3 antibody, Stk3 antibody, stk3.S antibody, stk3 antibody
- 背景
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Background: Stress-activated, pro-apoptotic kinase which, following caspase-cleavage, enters the nucleus and induces chromatin condensation followed by internucleosomal DNA fragmentation. Key component of the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. STK3/MST2 and STK4/MST1 are required to repress proliferation of mature hepatocytes, to prevent activation of facultative adult liver stem cells (oval cells), and to inhibit tumor formation. Phosphorylates NKX2-1 (By similarity). Phosphorylates NEK2 and plays a role in centrosome disjunction by regulating the localization of NEK2 to centrosome, and its ability to phosphorylate CROCC and CEP250. In conjunction with SAV1, activates the transcriptional activity of ESR1 through the modulation of its phosphorylation. Positively regulates RAF1 activation via suppression of the inhibitory phosphorylation of RAF1 on \\\'Ser-259\\\'. Phosphorylates MOBKL1A and RASSF2. Phosphorylates MOBKL1B on \\\'Thr-74\\\'. Acts cooperatively with MOBKL1B to activate STK38.
Aliases: 0610042I06Rik antibody, EC 2.7.11.1 antibody, FLJ90748 antibody, KB 1458E12.1 antibody, Kinase responsive to stress 1 antibody, KRS1 antibody, Mammalian STE20 like protein kinase 2 antibody, Mammalian STE20-like protein kinase 2 antibody, Mammalian sterile 20-like 2 antibody, Mess1 antibody, MST antibody, MST-2 antibody, MST2 antibody, Mst3 antibody, Serine/threonine kinase 3 (STE20 homolog, yeast) antibody, Serine/threonine kinase 3 (Ste20, yeast homolog) antibody, Serine/threonine kinase 3 antibody, Serine/threonine protein kinase 3 antibody, Serine/threonine protein kinase Krs1 antibody, Serine/threonine-protein kinase 3 antibody, Serine/threonine-protein kinase Krs-1 antibody, STE20 like kinase MST2 antibody, STE20-like kinase MST2 antibody, Stk3 antibody, STK3_HUMAN antibody, wu:fc19e11 antibody, zgc:55383 antibody
- UniProt
- Q13188
- 途径
- Tube Formation
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