MAD2L1 抗体
Quick Overview for MAD2L1 抗体 (ABIN6943982)
抗原
See all MAD2L1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant protein within human Mad2L1 aa 1-150
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亚型
- IgG
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anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) (C-Term) antibody
MAD2L1 适用: 人, 大鼠 WB, IF, IP, IHC (p), ICC 宿主: 兔 Polyclonal unconjugated
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) (AA 1-205) antibodyMAD2L1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 2E2-1D6 unconjugated
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) (AA 1-205) antibodyMAD2L1 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) (AA 1-174) antibodyMAD2L1 适用: 人 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibodyMAD2L1 适用: 人 WB, IP, IHC (p) 宿主: 小鼠 Monoclonal 17D10 unconjugated
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) (Internal Region) antibodyMAD2L1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) (AA 131-205) antibodyMAD2L1 适用: 人 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) (AA 2-205) antibodyMAD2L1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) (AA 1-205) antibodyMAD2L1 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1) antibodyMAD2L1 适用: 人, 小鼠, 大鼠 IHC, IF 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- MAD2L1 (MAD2 Mitotic Arrest Deficient-Like 1 (Yeast) (MAD2L1))
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别名
- Mad2L1
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背景
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Synonyms: Mitotic spindle assembly checkpoint protein MAD2A, Mitotic arrest deficient 2-like protein 1, HsMAD2, MAD2-like protein 1, MAD2L1, MAD2.
Background: Cell cycle progression is subject to arrest at the mitotic spindle assembly checkpoint in response to incorrect spindle fiber assembly. MAD2 (for mitotic arrest-deficient) is a component of the mitotic spindle checkpoint. Cells with mutated MAD2 do not undergo mitotic arrest in response to incorrect spindle fiber assembly, which results in missegregation and eventual cell death. A breast carcinoma cell line with reduced MAD2 expression, T47D, was shown to complete mitosis in the presence of nocodazole, an inhibitor of mitotic spindle assembly. MAD2 is localized to unattached kinetochores during prometaphase and disassociates upon spindle fiber attachment, indicating that MAD2 regulates kinetochore binding to the spindle fibers. Human MAD2 has also been shown to associate with insulin receptor (IR), but not IGFIR, implicating MAD2 as a mediator for IR-specific signaling. MAD2B, a MAD2 homolog, is required for the execution of the mitotic checkpoint monitoring the kinetochore-spindle attachment process and if the process is not complete, MAD2B delays the onset of anaphase.
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基因ID
- 4085
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UniProt
- Q13257
抗原
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