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HNRNPK 抗体

This anti-HNRNPK antibody is a 兔 单克隆 antibody detecting HNRNPK in WB, IHC, IHC (p) 和 IF (cc). Suitable for 人, 小鼠 和 大鼠.
产品编号 ABIN6943705
发货至: 中国

Quick Overview for HNRNPK 抗体 (ABIN6943705)

抗原

See all HNRNPK 抗体
HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

适用

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人, 小鼠, 大鼠

宿主

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克隆类型

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单克隆

标记

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This HNRNPK antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

克隆位点

8G5
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    N terminus Human HNRNPK

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    IHC()

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    HNRNPK (Heterogeneous Nuclear Ribonucleoprotein K (HNRNPK))

    别名

    HNRNPK

    背景

    Synonyms: Heterogeneous nuclear ribonucleoprotein K, Transformation up-regulated nuclear protein, hnRNP K, TUNP, HNRNPK

    Background: One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest.

    基因ID

    3190

    UniProt

    P61978
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