H2AFY 抗体
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北京 101111
Quick Overview for H2AFY 抗体 (ABIN6943601)
抗原
See all H2AFY 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant protein within human macroH2A.1 aa 150-300
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亚型
- IgG
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anti-H2A Histone Family, Member Y (H2AFY) (AA 109-369) antibody
H2AFY 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member Y (H2AFY) (AA 123-372) antibodyH2AFY 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member Y (H2AFY) (AA 123-372) antibodyH2AFY 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member Y (H2AFY) antibodyH2AFY 适用: 人, 大鼠, 小鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member Y (H2AFY) (AA 144-193) antibodyH2AFY 适用: 人, 大鼠, 小鼠, Cow, 马, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member Y (H2AFY) (N-Term) antibodyH2AFY 适用: 人, 大鼠, 小鼠, Cow, 马, 犬, 豚鼠, 兔, Pig, 猴, Bat, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member Y (H2AFY) (AA 36-85) antibodyH2AFY 适用: 人, 大鼠, 小鼠, Cow, 马, 犬, 豚鼠, 兔, Pig, 猴, 斑马鱼, Bat, 小鸡, 非洲爪蟾 WB 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member Y (H2AFY) (Middle Region) antibodyH2AFY 适用: 人, 大鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-H2A Histone Family, Member Y (H2AFY) (N-Term) antibodyH2AFY 适用: 人, 大鼠, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 12 months
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- H2AFY (H2A Histone Family, Member Y (H2AFY))
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别名
- H2AFY
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背景
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Synonyms: macroH2A.1, Core histone macro-H2A.1, Histone H2A.y, Medulloblastoma antigen MU-MB-50.205, Histone macroH2A1, mH2A1, H2A/y, H2AFY, MACROH2A1, H2A histone family member Y.
Background: Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machinery which requires DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. H2AFY is involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. H2AFY inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.
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基因ID
- 9555
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UniProt
- O75367
抗原
-
