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CXCR3 抗体

This anti-CXCR3 antibody is a 兔 单克隆 antibody detecting CXCR3 in WB, IHC (p) 和 IF (cc). Suitable for 人.
产品编号 ABIN6942741
发货至: 中国

Quick Overview for CXCR3 抗体 (ABIN6942741)

抗原

See all CXCR3 抗体
CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

适用

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宿主

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克隆类型

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单克隆

标记

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This CXCR3 antibody is un-conjugated

应用范围

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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

克隆位点

5F2
  • 交叉反应

    纯化方法

    Purified by Protein A.

    免疫原

    Human CXCR3 aa 250-350

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

    有效期

    12 months
  • 抗原

    CXCR3 (Chemokine (C-X-C Motif) Receptor 3 (CXCR3))

    别名

    CXCR3

    背景

    Synonyms: C-X-C chemokine receptor type 3, CKR-L2, G protein-coupled receptor 9, Interferon-inducible protein 10 receptor, CXC-R3, CXCR-3, IP-10 receptor, IP-10 receptor, CD183, CXCR3, GPR9

    Background: Isoform 1: Receptor for the C-X-C chemokine CXCL9, CXCL10 and CXCL11 and mediates the proliferation, survival and angiogenic activity of human mesangial cells (HMC) through a heterotrimeric G-protein signaling pathway. Binds to CCL21. Probably promotes cell chemotaxis response. Isoform 2: Receptor for the C-X-C chemokine CXCL4 and also mediates the inhibitory activities of CXCL9, CXCL10 and CXCL11 on the proliferation, survival and angiogenic activity of human microvascular endothelial cells (HMVEC) through a cAMP-mediated signaling pathway. Does not promote cell chemotaxis response. Interaction with CXCL4 or CXCL10 leads to activation of the p38MAPK pathway and contributes to inhibition of angiogenesis. Overexpression in renal cancer cells down-regulates expression of the anti-apoptotic protein HMOX1 and promotes apoptosis. Isoform 3: Mediates the activity of CXCL11.

    基因ID

    2833

    UniProt

    P49682
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