CDK9 抗体
Quick Overview for CDK9 抗体 (ABIN6942497)
抗原
See all CDK9 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant human Cdk9 protein, full length.
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亚型
- IgG
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anti-Cyclin-Dependent Kinase 9 (CDK9) antibody
CDK9 适用: 人 WB, IHC, IP, IF, ChIP-seq 宿主: 兔 Monoclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 153-372) antibodyCDK9 适用: 人 WB, IHC, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) antibodyCDK9 适用: 人 WB, ELISA, IHC 宿主: 小鼠 Monoclonal 1B5A7 unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 271-372) antibodyCDK9 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2D7 unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (Internal Region) antibodyCDK9 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 153-372) antibodyCDK9 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) antibodyCDK9 适用: 人, 小鼠, 大鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 104-315) antibodyCDK9 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 153-372) antibodyCDK9 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase 9 (CDK9) (AA 141-372) antibodyCDK9 适用: 人, 大鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB(1:1000), IHC-P(1:50-200), IF(ICC)(1:50-200)
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限制
- 仅限研究用
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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有效期
- 12 months
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- CDK9 (Cyclin-Dependent Kinase 9 (CDK9))
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别名
- Cdk9
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背景
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Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modifications including histone H2B monoubiquitination (H2Bub1), H3 lysine 4 trimethylation (H3K4me3) and H3K36me3, integrates phosphorylation during transcription with chromatin modifications to control co-transcriptional histone mRNA processing. The CDK9/cyclin-K complex has also a kinase activity towards CTD of RNAP II and can substitute for CDK9/cyclin-T P-TEFb in vitro. Replication stress response protein, the CDK9/cyclin-K complex is required for genome integrity maintenance, by promoting cell cycle recovery from replication arrest and limiting single-stranded DNA amount in response to replication stress, thus reducing the breakdown of stalled replication forks and avoiding DNA damage. In addition, probable function in DNA repair of isoform 2 via interaction with KU70/XRCC6. Promotes cardiac myocyte enlargement. RPB1/POLR2A phosphorylation on 'Ser-2' in CTD activates transcription. AR phosphorylation modulates AR transcription factor promoter selectivity and cell growth.
Synonyms: TAK, C-2k, CTK1, CDC2L4, PITALRE, Cyclin-dependent kinase 9, Cell division cycle 2-like protein kinase 4, Cell division protein kinase 9, Serine/threonine-protein kinase PITALRE, Tat-associated kinase complex catalytic subunit, CDK9 -
基因ID
- 1025
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UniProt
- P50750
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途径
- Cell Division Cycle
抗原
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