CD46 抗体 (AA 50-100)
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北京 101111
Quick Overview for CD46 抗体 (AA 50-100) (ABIN6942441)
抗原
See all CD46 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 50-100
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原理
- CD46 Recombinant Antibody
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交叉反应
- 人
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纯化方法
- Purified by Protein A.
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免疫原
- Synthetic peptide within human CD46 aa 50-100
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亚型
- IgG
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应用备注
- WB(WB(1:500-2000)), IHC-P(IHC-P(1:100-500)), IHC-F(IHC-F(1:100-500)), IF(IHC-P)(IF(IHC-P)(1:100-500)), IF(ICC)(IF(ICC)(1:50-200))
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- CD46
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别名
- CD46
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背景
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Synonyms: Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen, CD46, MCP, MIC10, AHUS2,
Background: Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement-mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T-cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and directly induce an immunosuppressive phenotype in T-cells by binding to CD46.
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基因ID
- 4179
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UniProt
- P15529
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途径
- Regulation of Actin Filament Polymerization
抗原
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