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CASP14 抗体

CASP14 适用: 人, 小鼠, 大鼠 WB, IHC, IHC (p), IF (cc), FACS 宿主: 兔 Monoclonal 8C4 unconjugated
产品编号 ABIN6942355
发货至: 中国
  • 抗原 See all CASP14 抗体
    CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))
    适用
    • 41
    • 18
    • 17
    • 1
    • 1
    人, 小鼠, 大鼠
    宿主
    • 39
    • 6
    • 1
    克隆类型
    • 31
    • 15
    单克隆
    标记
    • 32
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    This CASP14 antibody is un-conjugated
    应用范围
    • 28
    • 10
    • 8
    • 8
    • 7
    • 6
    • 5
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)
    交叉反应
    人, 小鼠, 大鼠
    纯化方法
    Purified by Protein A.
    免疫原
    Human Caspase-14 aa 100-200
    克隆位点
    8C4
    亚型
    IgG
    Top Product
    Discover our top product CASP14 Primary Antibody
  • 应用备注
    WB 1:300-5000
    FCM 1:20-100
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    IHC()
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C for 12 months.
    有效期
    12 months
  • 抗原
    CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))
    别名
    Caspase-14 (CASP14 产品)
    别名
    CASP14 antibody, MICE antibody, mini-ICE antibody, caspase 14, apoptosis-related cysteine peptidase antibody, caspase 14 antibody, caspase-14-like antibody, caspase-14 antibody, CASP14 antibody, Casp14 antibody, LOC485601 antibody, LOC780455 antibody
    背景

    Synonyms: Caspase-14, CASP-14, CASP14

    Background: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).

    基因ID
    23581
    UniProt
    P31944
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