CASP14 抗体 (AA 100-200)
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北京 101111
Quick Overview for CASP14 抗体 (AA 100-200) (ABIN6942355)
抗原
See all CASP14 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 100-200
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原理
- Caspase-14 (8C4) Monoclonal Antibody
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Human Caspase-14 aa 100-200
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亚型
- IgG
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应用备注
- WB(1:300-5000), FCM(1:200-400), IHC-P(1:50-200), IF(ICC)(1:50-200), IHC()
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- Lot specific
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- CASP14 (Caspase 14, Apoptosis-Related Cysteine Peptidase (CASP14))
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别名
- Caspase-14
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背景
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Synonyms: Caspase-14, CASP-14, CASP14
Background: Non-apoptotic caspase involved in epidermal differentiation. Is the predominant caspase in epidermal stratum corneum (PubMed:15556625). Seems to play a role in keratinocyte differentiation and is required for cornification. Regulates maturation of the epidermis by proteolytically processing filaggrin (By similarity). In vitro has a preference for the substate [WY]-X-X-D motif and is active on the synthetic caspase substrate WEHD-ACF (PubMed:16854378, PubMed:19960512). Involved in processing of prosaposin in the epidermis (By similarity). May be involved in retinal pigment epithelium cell barrier function (PubMed:25121097). Involved in DNA degradation in differentiated keratinocytes probably by cleaving DFFA/ICAD leading to liberation of DFFB/CAD (PubMed:24743736).
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基因ID
- 23581
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UniProt
- P31944
抗原
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