CAMK2D 抗体
Quick Overview for CAMK2D 抗体 (ABIN6942338)
抗原
See all CAMK2D 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠, 斑马鱼
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纯化方法
- Purified by Protein A.
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免疫原
- Human CAMK2D aa 1-100
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亚型
- IgG
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anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) antibody
KO Validated CAMK2D 适用: 人 WB, IF, IHC (p), ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 301-410) antibodyCAMK2D 适用: 人 WB, ELISA, IF, RNAi 宿主: 小鼠 Monoclonal 1A8 unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (Internal Region) antibodyCAMK2D 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) antibodyCAMK2D 适用: 人 WB, IF 宿主: 兔 Monoclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 221-250) antibodyCAMK2D 适用: 人, 小鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB34171 unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 1-260) antibodyCAMK2D 适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 301-410) antibodyCAMK2D 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 301-410) antibodyCAMK2D 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 2E1 unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (AA 448-478), (C-Term) antibodyCAMK2D 适用: 人, 大鼠 WB, IHC (p) 宿主: 兔 Polyclonal RB1259 unconjugated
anti-Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D) (C-Term) antibodyCAMK2D 适用: 人, 灵长类 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- CAMK2D (Calcium/calmodulin-Dependent Protein Kinase II delta (CAMK2D))
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别名
- CAMK2D
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背景
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Synonyms: Calcium/calmodulin-dependent protein kinase type II subunit delta, CaM kinase II subunit delta, CaMK-II subunit delta, CAMK2D, CAMKD, CaMKII delta
Background: Calcium/calmodulin-dependent protein kinase involved in the regulation of Ca2+ homeostatis and excitation-contraction coupling (ECC) in heart by targeting ion channels, transporters and accessory proteins involved in Ca2+ influx into the myocyte, Ca2+ release from the sarcoplasmic reticulum (SR), SR Ca2+ uptake and Na+ and K+ channel transport. Targets also transcription factors and signaling molecules to regulate heart function. In its activated form, is involved in the pathogenesis of dilated cardiomyopathy and heart failure. Contributes to cardiac decompensation and heart failure by regulating SR Ca2+ release via direct phosphorylation of RYR2 Ca2+ channel on 'Ser-2808'. In the nucleus, phosphorylates the MEF2 repressor HDAC4, promoting its nuclear export and binding to 14-3-3 protein, and expression of MEF2 and genes involved in the hypertrophic program. Is essential for left ventricular remodeling responses to myocardial infarction. In pathological myocardial remodeling acts downstream of the beta adrenergic receptor signaling cascade to regulate key proteins involved in ECC. Regulates Ca2+ influx to myocytes by binding and phosphorylating the L-type Ca2+ channel subunit beta-2 CACNB2. In addition to Ca2+ channels, can target and regulate the cardiac sarcolemmal Na+ channel Nav1.5/SCN5A and the K+ channel Kv4.3/KCND3, which contribute to arrhythmogenesis in heart failure. Phosphorylates phospholamban (PLN/PLB), an endogenous inhibitor of SERCA2A/ATP2A2, contributing to the enhancement of SR Ca2+ uptake that may be important in frequency-dependent acceleration of relaxation (FDAR) and maintenance of contractile function during acidosis. May participate in the modulation of skeletal muscle function in response to exercise, by regulating SR Ca2+ transport through phosphorylation of PLN/PLB and triadin, a ryanodine receptor-coupling factor.
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基因ID
- 817
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UniProt
- Q13557
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途径
- WNT signaling, Interferon-gamma Pathway, Myometrial Relaxation and Contraction, Smooth Muscle Cell Migration
抗原
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