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BAZ1B 抗体

This 兔 单克隆 anti-BAZ1B antibody (Clone 5G1) specifically detects BAZ1B in WB 和 FACS. The antibody is reactive with 人, 小鼠 和 大鼠 samples.
产品编号 ABIN6942236
发货至: 中国
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Room 801-803
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Quick Overview for BAZ1B 抗体 (ABIN6942236)

抗原

See all BAZ1B 抗体
BAZ1B (Bromodomain Adjacent To Zinc Finger Domain, 1B (BAZ1B))

适用

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人, 小鼠, 大鼠

宿主

  • 59
  • 5

克隆类型

  • 42
  • 22
单克隆

标记

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This BAZ1B antibody is un-conjugated

应用范围

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Western Blotting (WB), Flow Cytometry (FACS)

克隆位点

5G1
  • 交叉反应

    人, 小鼠, 大鼠

    纯化方法

    Purified by Protein A.

    免疫原

    Recombinant protein within C-terminal human BAZ1B.

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    FCM 1:20-100

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    4 °C,-20 °C

    储存方法

    Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

    有效期

    12 months
  • 抗原

    BAZ1B (Bromodomain Adjacent To Zinc Finger Domain, 1B (BAZ1B))

    别名

    BAZ1B

    背景

    Synonyms: Tyrosine-protein kinase BAZ1B, Bromodomain adjacent to zinc finger domain protein 1B, Williams syndrome transcription factor, Williams-Beuren syndrome chromosomal region 10 protein, Williams-Beuren syndrome chromosomal region 9 protein, hWALp2, BAZ1B, WBSC10, WBSCR10, WBSCR9, WSTF

    Background: Atypical tyrosine-protein kinase that plays a central role in chromatin remodeling and acts as a transcription regulator. Involved in DNA damage response by phosphorylating 'Tyr-142' of histone H2AX (H2AXY142ph). H2AXY142ph plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Essential component of the WICH complex, a chromatin remodeling complex that mobilizes nucleosomes and reconfigures irregular chromatin to a regular nucleosomal array structure. The WICH complex regulates the transcription of various genes, has a role in RNA polymerase I and RNA polymerase III transcription, mediates the histone H2AX phosphorylation at 'Tyr-142', and is involved in the maintenance of chromatin structures during DNA replication processes. In the complex, it mediates the recruitment of the WICH complex to replication foci during DNA replication.

    基因ID

    9031

    UniProt

    Q9UIG0

    途径

    Nuclear Hormone Receptor Binding, Chromatin Binding
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