ATF6 抗体 (AA 301-400)
Quick Overview for ATF6 抗体 (AA 301-400) (ABIN6942156)
抗原
See all ATF6 抗体适用
宿主
克隆类型
标记
应用范围
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抗原表位
- AA 301-400
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交叉反应
- 人, 小鼠, 大鼠
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预测反应
- Dog,Cow,Sheep,Pig,Horse,Rabbit
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纯化方法
- Purified by Protein A.
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免疫原
- KLH conjugated synthetic peptide derived from human ATF6
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亚型
- IgG
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anti-Activating Transcription Factor 6 (ATF6) (AA 1-190) antibody
ATF6 适用: 人 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 1-377) antibodyATF6 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 437-449) antibodyVerified ATF6 适用: 人 WB, ELISA, IF, FACS 宿主: 山羊 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 301-400) antibodyATF6 适用: 人 WB, ELISA, IF (p), IF (cc), IHC (p), FACS, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 350-377) antibodyATF6 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB22035 unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 350-377) antibodyATF6 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 423-646) antibodyATF6 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Activating Transcription Factor 6 (ATF6) (AA 91-193) antibodyATF6 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 3D5 unconjugated
anti-Activating Transcription Factor 6 (ATF6) (N-Term) antibodyATF6 适用: 人 WB, IP 宿主: 小鼠 Monoclonal 1-7 unconjugated
anti-Activating Transcription Factor 6 (ATF6) (N-Term) antibodyATF6 适用: 人, 小鼠 WB, IP 宿主: 小鼠 Monoclonal 37-1 unconjugated
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应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- ATF6 (Activating Transcription Factor 6 (ATF6))
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别名
- ATF6
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背景
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Synonyms: Activating transcription factor 6 alpha, Activating transcription factor 6, ATF 6, ATF6 alpha, ATF6, ATF6-alpha, ATF6A, ATF6A_HUMAN, cAMP dependent transcription factor ATF 6 alpha, cAMP-dependent transcription factor ATF-6 alpha, Cyclic AMP dependent transcription factor ATF 6 alpha, DKFZp686P2194, ESTM49, FLJ21663, Processed cyclic AMP dependent transcription factor ATF 6 alpha, Processed cyclic AMP-dependent transcription factor ATF-6 alpha.
Background: ATF6 is a transcription factor that acts during endoplasmic reticulum stress by activating unfolded protein response target genes. It binds DNA on the 5'-CCAC[GA]-3'half of the ER stress response element (ERSE) (5'-CCAAT-N(9)-CCAC[GA]-3') and of ERSE II (5'-ATTGG-N-CCACG-3'). Binding to ERSE requires binding of NF-Y to ERSE. ATF6 could also be involved in activation of transcription by the serum response factor. ATF6 exists as a homodimer and heterodimer with ATF6 beta. The dimer interacts with the nuclear transcription factor Y (NF-Y) trimer through direct binding to NF-Y subunit C (NF-YC). It also interacts with the transcription factors GTF2I, YY1 and SRF. Under ER stress the cleaved N-terminal cytoplasmic domain translocates into the nucleus. The basic domain of ATF6 functions as a nuclear localization signal and the basic leucine zipper domain is sufficient for association with the NF-Y trimer and binding to ERSE. During the unfolded protein response an approximately 50 kDa fragment containing the cytoplasmic transcription factor domain is released by proteolysis. The cleavage seems to be performed sequentially by site 1 and site 2 proteases. ATF6 is N glycosylated, phosphorylated in vitro by MAPK14/P38MAPK and belongs to the bZIP family.
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基因ID
- 22926
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UniProt
- P18850
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途径
- ER-Nucleus Signaling, Unfolded Protein Response
抗原
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