Aryl Hydrocarbon Receptor 抗体
Quick Overview for Aryl Hydrocarbon Receptor 抗体 (ABIN6942132)
抗原
See all Aryl Hydrocarbon Receptor (AHR) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
- 
    
- 
                                            
交叉反应
 - 人, 小鼠
 - 
                                            
纯化方法
 - Purified by Protein A.
 - 
                                            
免疫原
 - Human Aryl hydrocarbon Receptor aa 600-800
 - 
                                            
亚型
 - IgG
 
 - 
                                            
 - 
    
 - 
    
- 
                                            
应用备注
 - 
                        WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200 - 
                                            
限制
 - 仅限研究用
 
 - 
                                            
 - 
    
- 
                                            
状态
 - Liquid
 - 
                                            
浓度
 - 1 μg/μL
 - 
                                            
缓冲液
 - Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
 - 
                                            
储存液
 - ProClin
 - 
                                            
注意事项
 - This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
 - 
                                            
储存条件
 - -20 °C
 - 
                                            
储存方法
 - Store at -20°C for 12 months.
 - 
                                            
有效期
 - 12 months
 
 - 
                                            
 - 
    
- Aryl Hydrocarbon Receptor (AHR)
 - 
                                            
别名
 - Aryl hydrocarbon Receptor
 - 
                                            
背景
 - 
                        
Synonyms: Class E basic helix-loop-helix protein 76, Ah receptor, AhR, bHLHe76
Background: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).
 - 
                                            
基因ID
 - 196
 - 
                                            
UniProt
 - P35869
 - 
                                            
途径
 - Regulation of Cell Size
 
抗原
 -