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Aryl Hydrocarbon Receptor 抗体

This 兔 单克隆 antibody specifically detects Aryl Hydrocarbon Receptor in WB, IHC (p) 和 IF (cc). It exhibits reactivity toward 人 和 小鼠.
产品编号 ABIN6942132
发货至: 中国
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Quick Overview for Aryl Hydrocarbon Receptor 抗体 (ABIN6942132)

抗原

See all Aryl Hydrocarbon Receptor (AHR) 抗体
Aryl Hydrocarbon Receptor (AHR)

适用

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  • 1
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人, 小鼠

宿主

  • 120
  • 12
  • 5
  • 2

克隆类型

  • 100
  • 39
单克隆

标记

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This Aryl Hydrocarbon Receptor antibody is un-conjugated

应用范围

  • 97
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Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

克隆位点

3C7
  • 交叉反应

    人, 小鼠

    纯化方法

    Purified by Protein A.

    免疫原

    Human Aryl hydrocarbon Receptor aa 600-800

    亚型

    IgG
  • 应用备注

    WB 1:300-5000
    IHC-P 1:200-400
    IF(ICC) 1:50-200

    限制

    仅限研究用
  • 状态

    Liquid

    浓度

    1 μg/μL

    缓冲液

    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

    储存液

    ProClin

    注意事项

    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

    储存条件

    -20 °C

    储存方法

    Store at -20°C for 12 months.

    有效期

    12 months
  • 抗原

    Aryl Hydrocarbon Receptor (AHR)

    别名

    Aryl hydrocarbon Receptor

    背景

    Synonyms: Class E basic helix-loop-helix protein 76, Ah receptor, AhR, bHLHe76

    Background: Ligand-activated transcriptional activator. Binds to the XRE promoter region of genes it activates (PubMed:10395741, PubMed:28602820, PubMed:7961644, PubMed:23275542, PubMed:30373764). Activates the expression of multiple phase I and II xenobiotic chemical metabolizing enzyme genes (such as the CYP1A1 gene) (PubMed:7961644). Mediates biochemical and toxic effects of halogenated aromatic hydrocarbons (PubMed:7961644). Involved in cell-cycle regulation (PubMed:12213388). Likely to play an important role in the development and maturation of many tissues (PubMed:12213388). Regulates the circadian clock by inhibiting the basal and circadian expression of the core circadian component PER1 (PubMed:28602820). Inhibits PER1 by repressing the CLOCK-ARNTL/BMAL1 heterodimer mediated transcriptional activation of PER1. The heterodimer ARNT:AHR binds to core DNA sequence 5'-TGCGTG-3' within the dioxin response element (DRE) of target gene promoters and activates their transcription (PubMed:28602820).

    基因ID

    196

    UniProt

    P35869

    途径

    Regulation of Cell Size
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