ARHGEF2 抗体
Quick Overview for ARHGEF2 抗体 (ABIN6942130)
抗原
See all ARHGEF2 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant protein corresponding to C-terminal human GEF H1.
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亚型
- IgG
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anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 21-120) antibody
ARHGEF2 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (Tyr427) antibodyARHGEF2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (pSer886) antibodyARHGEF2 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 小鼠 WB, IP, IF 宿主: 绵羊 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 590-690) antibodyARHGEF2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 383-432) antibodyARHGEF2 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 1-959) antibodyARHGEF2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (C-Term) antibodyARHGEF2 适用: 人, 小鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
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有效期
- 12 months
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- ARHGEF2 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2))
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别名
- ARHGEF2
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背景
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Synonyms: Rho guanine nucleotide exchange factor 2, Guanine nucleotide exchange factor H1, Microtubule-regulated Rho-GEF, Proliferating cell nucleolar antigen p40, GEF-H1, ARHGEF2, KIAA0651, LFP40
Background: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans, acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2.
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基因ID
- 9181
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UniProt
- Q92974
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途径
- Negative Regulation of intrinsic apoptotic Signaling
抗原
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