ARHGEF2 抗体 (C-Term)
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- 抗原 See all ARHGEF2 抗体
- ARHGEF2 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2))
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抗原表位
- C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This ARHGEF2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunocytochemistry (ICC)
- 特异性
- GEF H1 Antibody detects endogenous levels of total GEF H1.
- 预测反应
- Pig,Bovine,Horse,Sheep,Rabbit,Dog,Xenopus
- 纯化方法
- The antiserum was purified by peptide affinity chromatography using SulfoLinkTM Coupling Resin (Thermo Fisher Scientific).
- 免疫原
- A synthesized peptide derived from human GEF H1, corresponding to a region within C-terminal amino acids.
- 亚型
- IgG
- Top Product
- Discover our top product ARHGEF2 Primary Antibody
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anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 21-120) antibody
ARHGEF2 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 人, 小鼠, 大鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (Tyr427) antibodyARHGEF2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (pSer886) antibodyARHGEF2 适用: 人 WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 小鼠 WB, IP, IF 宿主: 绵羊 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 590-690) antibodyARHGEF2 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 小鼠 IHC 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 694-743) antibodyARHGEF2 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) (AA 1-959) antibodyARHGEF2 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2) antibodyARHGEF2 适用: 小鼠 WB 宿主: 绵羊 Polyclonal unconjugated
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- 应用备注
- WB 1:500-1:1000, IF/ICC 1:100-1:500, ELISA(peptide) 1:20000-1:40000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Rabbit IgG in phosphate buffered saline , pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20 °C. Stable for 12 months from date of receipt.
- 有效期
- 12 months
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- 抗原
- ARHGEF2 (rho/rac Guanine Nucleotide Exchange Factor (GEF) 2 (ARHGEF2))
- 别名
- ARHGEF2 (ARHGEF2 产品)
- 别名
- MGC82333 antibody, MGC86214 antibody, MGC75855 antibody, AA408978 antibody, GEF antibody, GEF-H1 antibody, GEFH1 antibody, LFP40 antibody, Lbcl1 antibody, Lfc antibody, P40 antibody, mKIAA0651 antibody, GEF-H1/LFC antibody, Rho/Rac guanine nucleotide exchange factor 2 antibody, Rho/Rac guanine nucleotide exchange factor 2 S homeolog antibody, rho/rac guanine nucleotide exchange factor (GEF) 2 antibody, ARHGEF2 antibody, arhgef2.S antibody, arhgef2 antibody, Arhgef2 antibody
- 背景
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Description: Activates Rho-GTPases by promoting the exchange of GDP for GTP. May be involved in epithelial barrier permeability, cell motility and polarization, dendritic spine morphology, antigen presentation, leukemic cell differentiation, cell cycle regulation, innate immune response, and cancer. Binds Rac-GTPases, but does not seem to promote nucleotide exchange activity toward Rac-GTPases, which was uniquely reported in PubMed:9857026. May stimulate instead the cortical activity of Rac. Inactive toward CDC42, TC10, or Ras-GTPases. Forms an intracellular sensing system along with NOD1 for the detection of microbial effectors during cell invasion by pathogens. Required for RHOA and RIP2 dependent NF-kappaB signaling pathways activation upon S.flexneri cell invasion. Involved not only in sensing peptidoglycan (PGN)-derived muropeptides through NOD1 that is independent of its GEF activity, but also in the activation of NF-kappaB by Shigella effector proteins (IpgB2 and OspB) which requires its GEF activity and the activation of RhoA. Involved in innate immune signaling transduction pathway promoting cytokine IL6/interleukin-6 and TNF-alpha secretion in macrophage upon stimulation by bacterial peptidoglycans, acts as a signaling intermediate between NOD2 receptor and RIPK2 kinase. Contributes to the tyrosine phosphorylation of RIPK2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Overexpression activates Rho-, but not Rac-GTPases, and increases paracellular permeability (By similarity). Involved in neuronal progenitor cell division and differentiation (PubMed:28453519). Involved in the migration of precerebellar neurons (By similarity).
Gene: ARHGEF2
- 分子量
- 101 kDa
- 基因ID
- 9181
- UniProt
- Q92974
- 途径
- Negative Regulation of intrinsic apoptotic Signaling
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