Angiopoietin 1 抗体
Quick Overview for Angiopoietin 1 抗体 (ABIN6942099)
抗原
See all Angiopoietin 1 (ANGPT1) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 大鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Human Angiopoietin 1 between 250-350 amino acids
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亚型
- IgG
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anti-Angiopoietin 1 (ANGPT1) (AA 304-450) antibody
ANGPT1 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 260-400) antibodyANGPT1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (Internal Region) antibodyVerified ANGPT1 适用: 人 WB, ELISA, FACS, IF 宿主: 山羊 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 276-375) antibodyANGPT1 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 284-452) antibodyANGPT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 21-228) antibodyANGPT1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 253-429) antibodyANGPT1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 284-452) antibodyANGPT1 适用: 人 WB 宿主: 小鼠 Monoclonal E1 unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 148-266) antibodyANGPT1 适用: 犬 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Angiopoietin 1 (ANGPT1) (AA 16-498) antibodyANGPT1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
- WB 1:300-5000
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限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- -20 °C
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储存方法
- Store at -20°C for 12 months.
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有效期
- 12 months
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- Angiopoietin 1 (ANGPT1)
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别名
- Angiopoietin 1
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背景
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Synonyms: Angiopoietin-1, ANG-1, ANGPT1
Background: Binds and activates TEK/TIE2 receptor by inducing its dimerization and tyrosine phosphorylation. Plays an important role in the regulation of angiogenesis, endothelial cell survival, proliferation, migration, adhesion and cell spreading, reorganization of the actin cytoskeleton, but also maintenance of vascular quiescence. Required for normal angiogenesis and heart development during embryogenesis. After birth, activates or inhibits angiogenesis, depending on the context. Inhibits angiogenesis and promotes vascular stability in quiescent vessels, where endothelial cells have tight contacts. In quiescent vessels, ANGPT1 oligomers recruit TEK to cell-cell contacts, forming complexes with TEK molecules from adjoining cells, and this leads to preferential activation of phosphatidylinositol 3-kinase and the AKT1 signaling cascades. In migrating endothelial cells that lack cell-cell adhesions, ANGT1 recruits TEK to contacts with the extracellular matrix, leading to the formation of focal adhesion complexes, activation of PTK2/FAK and of the downstream kinases MAPK1/ERK2 and MAPK3/ERK1, and ultimately to the stimulation of sprouting angiogenesis. Mediates blood vessel maturation/stability. Implicated in endothelial developmental processes later and distinct from that of VEGF. Appears to play a crucial role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme.
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基因ID
- 284
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UniProt
- Q15389
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途径
- RTK signaling, Glycosaminoglycan Metabolic Process
抗原
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