BAF53A 抗体
Quick Overview for BAF53A 抗体 (ABIN6942044)
抗原
See all BAF53A 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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交叉反应
- 人, 小鼠
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纯化方法
- Purified by Protein A.
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免疫原
- Recombinant protein within human ACTL6A aa 1-200
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亚型
- IgG
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anti-Actin-Like 6A (BAF53A) (AA 1-280) antibody
BAF53A 适用: 人 WB, ELISA, IHC, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6A (BAF53A) (AA 295-320), (C-Term) antibodyBAF53A 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB51048 unconjugated
anti-Actin-Like 6A (BAF53A) (AA 1-80) antibodyBAF53A 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C4 unconjugated
anti-Actin-Like 6A (BAF53A) antibodyBAF53A 适用: 人 WB, ELISA, IF 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6A (BAF53A) (Internal Region) antibodyBAF53A 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6A (BAF53A) (Center) antibodyBAF53A 适用: 人, 小鼠, 大鼠, Cow, 犬, 小鸡, Pig WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6A (BAF53A) (AA 331-410) antibodyBAF53A 适用: 小鼠, 大鼠 WB, ELISA, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Actin-Like 6A (BAF53A) (AA 55-89), (N-Term) antibodyBAF53A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB51668 unconjugated
anti-Actin-Like 6A (BAF53A) (AA 295-330), (C-Term) antibodyBAF53A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB50976 unconjugated
anti-Actin-Like 6A (BAF53A) (AA 1-429) antibodyBAF53A 适用: 人 IP 宿主: 兔 Polyclonal unconjugated
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应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 -
限制
- 仅限研究用
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状态
- Liquid
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浓度
- 1 μg/μL
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缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
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储存液
- ProClin
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注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
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储存条件
- 4 °C,-20 °C
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储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
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有效期
- 12 months
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- BAF53A (Actin-Like 6A (BAF53A))
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别名
- ACTL6A
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背景
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Synonyms: Actin-like protein 6A, 53 kDa BRG1-associated factor A, Actin-related protein Baf53a, ArpNbeta, BRG1-associated factor 53A, INO80 complex subunit K, BAF53A, ACTL6A, BAF53, INO80K.
Background: Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Required for maximal ATPase activity of SMARCA4/BRG1/BAF190A and for association of the SMARCA4/BRG1/BAF190A containing remodeling complex BAF with chromatin/nuclear matrix. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and is required for the proliferation of neural progenitors. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Putative core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair.
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基因ID
- 86
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UniProt
- O96019
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途径
- Chromatin Binding, Photoperiodism
抗原
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