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- 抗原 See all XRCC3 抗体
- XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This XRCC3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant full-length human XRCC3 protein
- 克隆位点
- 10F1-6
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product XRCC3 Primary Antibody
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anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (AA 62-346) antibody
XRCC3 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (AA 1-346) antibodyXRCC3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (N-Term) antibodyXRCC3 适用: 人, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (N-Term) antibodyXRCC3 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (AA 41-90) antibodyXRCC3 适用: 人 WB, ELISA, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (AA 41-90) antibodyXRCC3 适用: 人 ELISA, IHC, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) antibodyXRCC3 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (C-Term) antibodyXRCC3 适用: 人 WB, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) antibodyXRCC3 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3) (Internal Region) antibodyXRCC3 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Positive Control: Human placenta. HeLa nuclear extract.
Known Application: Western Blot (0.5-1 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- XRCC3 (X-Ray Repair Complementing Defective Repair in Chinese Hamster Cells 3 (XRCC3))
- 别名
- XRCC3 (XRCC3 产品)
- 别名
- CMM6 antibody, 4432412E01Rik antibody, AI182522 antibody, AW537713 antibody, MGC69118 antibody, im:7142103 antibody, zgc:101608 antibody, si:dkey-11b8.1 antibody, xrcc3 antibody, XRCC3 antibody, X-ray repair cross complementing 3 antibody, X-ray repair complementing defective repair in Chinese hamster cells 3 antibody, X-ray repair complementing defective repair in Chinese hamster cells 3 L homeolog antibody, XRCC3 antibody, Xrcc3 antibody, xrcc3.L antibody, xrcc3 antibody
- 背景
- The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad51. XRCC1 is a protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA Ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA Ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA Ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.
- 分子量
- 40kDa
- 基因ID
- 7517
- UniProt
- O43542
- 途径
- DNA Damage Repair
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