TPO (AA 685-804) 抗体
Quick Overview for TPO (AA 685-804) 抗体 (ABIN6940796)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
抗原表位
- AA 685-804
-
纯化方法
- Purified by Protein A/G
-
免疫原
- Recombinant fragment of human TPO (around aa 685-804) (Exact sequence is proprietary)
-
亚型
- IgG1 kappa
-
-
anti-TPO antibody
适用: 人 IHC 宿主: 兔 Monoclonal unconjugated
anti-TPO (AA 685-804) antibody适用: 人 IHC, StM 宿主: 兔 Monoclonal TPO-3813R unconjugated Recombinant Antibody
anti-TPO (AA 19-846) antibody适用: 人 IHC, ELISA 宿主: 兔 Polyclonal unconjugated
-
-
应用备注
-
Positive Control: Thyroid Carcinoma.
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.
-
限制
- 仅限研究用
-
-
-
浓度
- 200 μg/mL
-
缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-80 °C
-
储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
-
有效期
- 24 months
-
-
- TPO
-
物质类
- Viral Protein
-
背景
- Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.
-
分子量
- 100kDa
-
基因ID
- 7173
-
UniProt
- P07202
抗原
-
