Chp2 抗体
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北京 101111
Quick Overview for Chp2 抗体 (ABIN6940567)
抗原
适用
宿主
克隆类型
标记
应用范围
克隆位点
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纯化方法
- Purified by Protein A/G
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免疫原
- Recombinant human full-length CHP2 protein
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亚型
- IgG2c kappa
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anti-Chp2 (Internal Region) antibody
适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Internal Region) antibody适用: 人, 小鼠, 大鼠 WB, IF, ELISA, ICC, IHC 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Internal Region) antibody适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (Center) antibody适用: 人, 小鼠, 大鼠, 猴 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Chp2 (AA 101-150) antibody适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Positive Control: MCF-7, PC-3, HT29, K562 or Jurkat cell lysates. Human appendix or testis.
Known Application: Western Blot (1-2 μg/mL), Immunofluorescence (1-2 μg/mL),Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- Chp2
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背景
- CHP2 (calcineurin B homologous protein 2), also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
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分子量
- 22kDa
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基因ID
- 63928
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UniProt
- O43745
抗原
-
