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- 抗原 See all PLK1.S products
- PLK1.S (Serine/threonine-Protein Kinase PLK1 (PLK1.S))
- 适用
- 非洲爪蟾
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PLK1.S antibody is un-conjugated
- 应用范围
- Coating (Coat), ELISA, Western Blotting (WB)
- 无交叉反应
- 人, 小鼠
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant full-length PLK1 Xenopus laevis protein
- 克隆位点
- AZ44
- 亚型
- IgG1 kappa
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- 应用备注
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Positive Control: Mitotic CSF Xenopus egg extract.
Known Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- PLK1.S (Serine/threonine-Protein Kinase PLK1 (PLK1.S))
- 别名
- plk1.S (PLK1.S 产品)
- 背景
- Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and Cdc5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle, Plk protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Useful for confirming that extracts have maintained CSF status and have not yet been activated into interphase.
- 分子量
- 66kDa
- 基因ID
- 380481
- UniProt
- P70032
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