PLK1.S 抗体
PLK1.S
适用: 非洲爪蟾
Coat, ELISA, WB
宿主: 小鼠
Monoclonal
AZ44
unconjugated
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- 抗原 See all PLK1.S products
- PLK1.S (Serine/threonine-Protein Kinase PLK1 (PLK1.S))
- 适用
- 非洲爪蟾
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PLK1.S antibody is un-conjugated
- 应用范围
- Coating (Coat), ELISA, Western Blotting (WB)
- 特异性
- Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and Cdc5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle, Plk protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation. Required for recovery after DNA damage checkpoint and entry into mitosis. Required for kinetochore localization of BUB1B. Phosphorylates SGOL1. Required for spindle pole localization of isoform 3 of SGOL1 and plays a role in regulating its centriole cohesion function. Phosphorylates BORA, and thereby promotes the degradation of BORA. Contributes to the regulation of AURKA function. Regulates TP53 stability through phosphorylation of TOPORS. Useful for confirming that extracts have maintained CSF status and have not yet been activated into interphase.
- 无交叉反应
- 人, 小鼠
- 交叉反应 （详细）
- Xenopus laevis. Does not react with Human or Mouse.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length PLK1 Xenopus laevis protein
- 克隆位点
- AZ44
- 亚型
- IgG1 kappa
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anti-Serine/threonine-Protein Kinase PLK1 (PLK1.S) antibody
PLK1.S 适用: 非洲爪蟾 Coat, ELISA, WB 宿主: 小鼠 Monoclonal AZ44 unconjugated
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- 应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL), Optimal dilution for a specific application should be determined.
Positive_Control: Mitotic CSF Xenopus egg extract.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- PLK1.S (Serine/threonine-Protein Kinase PLK1 (PLK1.S))
- 别名
- plk1.S (PLK1.S 产品)
- 背景
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Cell cycle regulated protein kinase, Polo like kinase 1 (PLK1), Serine/threonine-protein kinase PLK1, STPK13,PLK1 (Marker of Mitosis)
Cellular localisation: Nucleus and cytoplasm. - 分子量
- 66kDa
- 基因ID
- 380481, 28141
- UniProt
- P70032
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