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CD11b 抗体 (AA 941-1074)

This anti-CD11b antibody is a 小鼠 单克隆 antibody detecting CD11b in IHC, WB 和 StM. Suitable for 人.
产品编号 ABIN6939810
发货至: 中国

Quick Overview for CD11b 抗体 (AA 941-1074) (ABIN6939810)

抗原

See all CD11b (ITGAM) 抗体
CD11b (ITGAM) (Integrin alpha M (ITGAM))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This CD11b antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Western Blotting (WB), Staining Methods (StM)

克隆位点

ITGAM-3340
  • 抗原表位

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    AA 941-1074

    纯化方法

    Purified by Protein A/G

    免疫原

    Recombinant fragment (around aa941-1074) of human ITGAM protein (exact sequence is proprietary)

    亚型

    IgG2a kappa
  • 应用备注

    Positive Control: Monocytes & granulocytes. Lymph nodes, spleen and tonsil (IHC).

    Known Application: Western Blot (0.5-1.0 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-80 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    有效期

    24 months
  • 抗原

    CD11b (ITGAM) (Integrin alpha M (ITGAM))

    别名

    ITGAM

    背景

    CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin aM combines with the Integrin '2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin aM/'2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b andCD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.

    分子量

    95kDa & 170kDa

    基因ID

    3684

    UniProt

    P11215

    途径

    Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation
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