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GZMB 抗体 (AA 73-187)

This anti-GZMB antibody is a 小鼠 单克隆 antibody detecting GZMB in IHC, ELISA 和 Coat. Suitable for 人.
产品编号 ABIN6939590
发货至: 中国

Quick Overview for GZMB 抗体 (AA 73-187) (ABIN6939590)

抗原

See all GZMB 抗体
GZMB (Granzyme B (GZMB))

适用

  • 178
  • 51
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宿主

  • 94
  • 92
  • 2
小鼠

克隆类型

  • 101
  • 87
单克隆

标记

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  • 1
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  • 1
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  • 1
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This GZMB antibody is un-conjugated

应用范围

  • 92
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Immunohistochemistry (IHC), ELISA, Coating (Coat)

克隆位点

GZMB-2403
  • 抗原表位

    • 52
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    • 16
    • 10
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    • 2
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    • 2
    • 2
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    • 1
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    • 1
    • 1
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    AA 73-187

    纯化方法

    Purified by Protein A/G

    免疫原

    Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary)

    亚型

    IgG2b kappa
  • 应用备注

    Positive Control: A431 cells. Human tonsil, spleen or Hodgkin's Lymphoma tissue (IHC).

    Known Application: ELISA (For coating use Ab at 1-5 μg/mL, order Ab without BSA) Optimal dilution for a specific application should be determined.

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-80 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    有效期

    24 months
  • 抗原

    GZMB (Granzyme B (GZMB))

    别名

    GZMB

    背景

    Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.

    分子量

    29-32kDa

    基因ID

    3002

    UniProt

    P10144

    途径

    Apoptosis, Caspase Cascade in Apoptosis
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