GZMB 抗体 (AA 73-187)
Quick Overview for GZMB 抗体 (AA 73-187) (ABIN6939590)
抗原
See all GZMB 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 73-187
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纯化方法
- Purified by Protein A/G
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免疫原
- Recombinant fragment of human GZMB protein (around aa 73-187) (exact sequence is proprietary)
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亚型
- IgG2b kappa
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应用备注
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Positive Control: A431 cells. Human tonsil, spleen or Hodgkin's Lymphoma tissue (IHC).
Known Application: ELISA (For coating use Ab at 1-5 μg/mL, order Ab without BSA) Optimal dilution for a specific application should be determined.
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限制
- 仅限研究用
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浓度
- 200 μg/mL
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缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
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储存液
- Sodium azide
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注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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储存条件
- 4 °C,-80 °C
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储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
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有效期
- 24 months
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- GZMB (Granzyme B (GZMB))
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别名
- GZMB
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背景
- Granzyme B is a member of the granule serine protease family stored specifically in NK cells or cytotoxic T cells. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. Granzyme B is crucial for the rapid induction of target cell apoptosis by CTLs in the cell-mediated immune response. Granzyme B is useful as a marker in the identification of NK/T-cell lymphomas. High percentages of cytotoxic T-cells have been shown to be an unfavorable prognostic indicator in Hodgkin's Disease.
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分子量
- 29-32kDa
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基因ID
- 3002
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UniProt
- P10144
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途径
- Apoptosis, Caspase Cascade in Apoptosis
抗原
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