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FcRn 抗体 (AA 24-215)

This anti-FcRn antibody is a 小鼠 单克隆 antibody detecting FcRn in IHC, ISt 和 StM. Suitable for 人.
产品编号 ABIN6939380
发货至: 中国

Quick Overview for FcRn 抗体 (AA 24-215) (ABIN6939380)

抗原

See all FcRn 抗体
FcRn (neonatal Fc Receptor (FcRn))

适用

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宿主

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小鼠

克隆类型

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单克隆

标记

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This FcRn antibody is un-conjugated

应用范围

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Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)

克隆位点

FCGRT-2932
  • 抗原表位

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    AA 24-215

    纯化方法

    Purified by Protein A/G

    免疫原

    Recombinant fragment of human FCGRT protein (around aa 24-215) (Exact sequence is proprietary)

    亚型

    IgG2b kappa
  • 应用备注

    Positive Control: THP1 or HepG2 cells. Cerebellum or Testis.

    Known Application: Immunohistochemistry (Formalin-fixed) (2-4 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    限制

    仅限研究用
  • 浓度

    200 μg/mL

    缓冲液

    10 mM PBS with 0.05 % BSA & 0.05 % azide.

    储存液

    Sodium azide

    注意事项

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    储存条件

    4 °C,-80 °C

    储存方法

    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

    有效期

    24 months
  • 抗原

    FcRn (neonatal Fc Receptor (FcRn))

    别名

    FCGRT

    背景

    This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.

    分子量

    46kDa

    基因ID

    2217

    UniProt

    P55899

    途径

    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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