BTLA 抗体
Quick Overview for BTLA 抗体 (ABIN6939222)
抗原
See all BTLA 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
-
-
纯化方法
- Purified by Protein A/G
-
免疫原
- Recombinant full-length human BTLA protein
-
亚型
- IgG2b kappa
-
-
-
-
应用备注
-
Positive Control: Human lymph node or MDAMB468 xenograft.
Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.
-
限制
- 仅限研究用
-
-
-
浓度
- 200 μg/mL
-
缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
-
储存液
- Sodium azide
-
注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
-
储存条件
- 4 °C,-80 °C
-
储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
-
有效期
- 24 months
-
-
- BTLA (B and T Lymphocyte Associated (BTLA))
-
别名
- BTLA
-
背景
- B and T lymphocyte attenuator (BTLA) is an immunoglobulin domain-containing glycoprotein whose expression is induced during T-cell activation. BTLA is similar to CTLA-4 and PD-1, all of which are coinhibitory receptors belonging to the CD28 family. However, unlike CTLA-4 and PD-1, BTLA does not interact with B7-Ig family counter receptors. Rather, the herpesvirus entry mediator (HVEM), a TNF receptor, acts as a molecular switch that modulates T-cell activation by propagating inhibitory signals through BTLA. The BTLAHVEM interaction is conserved between Mouse and human, suggesting that this system is an important pathway regulating lymphocyte activation.
-
分子量
- 33kDa
-
基因ID
- 151888
-
途径
- Cancer Immune Checkpoints
抗原
-