STAT5B 抗体
Quick Overview for STAT5B 抗体 (ABIN6938461)
抗原
See all STAT5B 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- Signal transducer and activator of transcription 5A (Stat5a) and Stat5b, which share 96 % homology, undergo receptor tyrosine kinase or G protein-coupled receptor-dependent phosphorylation in response to cytokines or growth factors, and then form homo- or heterodimers that translocate to the nucleus, where they initiate transcription. Activation of Stat5a via IL-2, IL-3, IL-7/ GM-CSF, erythropoietin, thrombopoietin and growth hormones influences proliferation, differentiation and apoptosis in lymphohematopoietic cells. Phosphorylation of Stat5a at Ser127/Ser128 and Ser779 are contigent on ErbB-4-mediated activation of Stat5a. Activation of Stat5b via IL-2, IL-4, CSF-1 and growth hormones influences TCR signaling, apoptosis, adult mammary gland development and sexual dimorphism of liver gene expression. Stat5b is the major liver-expressed Stat5 form that has been shown to fuse with the retinoic acid receptor a gene in acute promyelocytic leukemias (APLL). Stat5a/b null mice have severely impaired lymphoid development and differentiation.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant full-length human STAT5B protein
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亚型
- IgG
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anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-390) antibody
STAT5B 适用: 人 WB, ELISA, IP 宿主: 小鼠 Monoclonal 1C2 unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 678-787) antibodySTAT5B 适用: 人 WB, ELISA, IF, IHC (p) 宿主: 小鼠 Monoclonal 2D1 unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 1-390) antibodySTAT5B 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1A1 unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) antibodySTAT5B 适用: 人 WB, IHC (p) 宿主: 兔 Monoclonal 12A1 unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 40-280) antibodySTAT5B 适用: 人 WB, IHC, ELISA, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 40-280) antibodySTAT5B 适用: 人 WB, IHC, ELISA, ChIP 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (AA 180-229) antibodySTAT5B 适用: 人, Cow, 犬, 马, Pig, 绵羊 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (N-Term) antibodySTAT5B 适用: 人, 小鼠, 大鼠, 犬, 马, Pig, 兔, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) (pSer731) antibodySTAT5B 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Signal Transducer and Activator of Transcription 5B (STAT5B) antibodyKO Validated STAT5B 适用: 人 WB, IP 宿主: 兔 Monoclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human spleen.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- STAT5B (Signal Transducer and Activator of Transcription 5B (STAT5B))
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别名
- STAT5B
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背景
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Signal transducer and activator of transcription 5B, STAT5, Stat5b, Transcription factor STAT5B,STAT5B
Cellular localisation: Cytoplasm & Nucleus. Translocated into the nucleus in response to phosphorylation. -
分子量
- 94kDa
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基因ID
- 6777, 595276
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UniProt
- P51692
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途径
- JAK/STAT Signaling, RTK signaling, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation
抗原
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