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Ret Proto-Oncogene 抗体 (AA 702-848)

RET 适用: 人 IHC (f) 宿主: 小鼠 Monoclonal RET-2795 unconjugated
产品编号 ABIN6938320
发货至: 中国
  • 抗原 See all Ret Proto-Oncogene (RET) 抗体
    Ret Proto-Oncogene (RET)
    抗原表位
    • 27
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    AA 702-848
    适用
    • 161
    • 100
    • 81
    • 5
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    • 2
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    • 1
    • 1
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    宿主
    • 185
    • 21
    • 2
    • 1
    • 1
    • 1
    小鼠
    克隆类型
    • 181
    • 30
    单克隆
    标记
    • 88
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    This Ret Proto-Oncogene antibody is un-conjugated
    应用范围
    • 170
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    • 42
    • 28
    • 17
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    Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    特异性
    The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney.Alterations in RETgene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung's disease.
    交叉反应 (详细)
    Human.
    纯化方法
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    免疫原
    Recombinant fragment (around aa 702-848) of human RET protein (exact sequence is proprietary)
    克隆位点
    RET-2795
    亚型
    IgG1 kappa
    Top Product
    Discover our top product RET Primary Antibody
  • 应用备注

    Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Positive_Control: Breast, Prostate or Colon Carcinoma.

    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    储存液
    Azide free
    储存条件
    -20 °C,-80 °C
    储存方法
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    有效期
    24 months
  • 抗原
    Ret Proto-Oncogene (RET)
    别名
    RET (RET 产品)
    别名
    c-ret antibody, cret antibody, etID315074.13 antibody, ret1 antibody, wu:fd13h01 antibody, X-ret antibody, ret-A antibody, xret antibody, RET antibody, MTC1 antibody, CDHF12 antibody, CDHR16 antibody, HSCR1 antibody, MEN2A antibody, MEN2B antibody, PTC antibody, RET-ELE1 antibody, RET51 antibody, RET9 antibody, c-Ret antibody, ret proto-oncogene receptor tyrosine kinase antibody, ret proto-oncogene S homeolog antibody, ret proto-oncogene antibody, ret antibody, ret.S antibody, RET antibody, Ret antibody
    背景
    Cadherin family member 12 (CDHF12), Cadherin related family member 16 (CDHR16), ELKS, HSCR1, Hydroxyaryl protein kinase, MEN2A, MEN2B, MTC1, Multiple endocrine neoplasia and medullary thyroid carcinoma 1, Oncogene RET, Proto-oncogene c-Ret, Proto-oncogene tyrosine-protein kinase receptor ret, PTC, RET, RET ELE1, RET51, RET9,RET Proto-oncogene
    Cellular localisation: Cytoplasmic, Cell Surface and Nuclear
    分子量
    150kDa (precursor), 170kDa (Mature)
    基因ID
    5979, 350321
    UniProt
    P07949
    途径
    RTK signaling, Dopaminergic Neurogenesis, Regulation of Cell Size, Tube Formation
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