SHP1 抗体
Quick Overview for SHP1 抗体 (ABIN6938266)
抗原
See all SHP1 (PTPN6) 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- APEX / APE1 is a multifunctional protein that plays a central role in the cellular response to oxidative stress. The two major activities of APEX1 in DNA repair and redox regulation of transcriptional factors. Functions as a apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Patients with genetic variants in APEX1 and XRCC1 have been shown to have a higher risk of lung cancer. Elevated APEX1 levels observed in human testicular cancer may be related to relative resistance to therapy and therefore may serve as a diagnostic marker for refractory disease.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human full-length APEX1 protein
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亚型
- IgG1 kappa
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anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibody
PTPN6 适用: 人 WB, IHC, IF, FACS, StM 宿主: 小鼠 Monoclonal CPTC-APEX1-2 unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibodyPTPN6 适用: 人 WB, IHC (p), IP, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 1-595) antibodyPTPN6 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 243-541) antibodyPTPN6 适用: 人 ELISA, FACS, ICC 宿主: 小鼠 Monoclonal 2E9E4 unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 1-597), (Isoform 2) antibodyPTPN6 适用: 人 WB, ELISA, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (C-Term) antibodyPTPN6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (pTyr536) antibodyPTPN6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 100-400) antibodyPTPN6 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) (AA 247-277) antibodyPTPN6 适用: 人 WB, IF, IHC (p) 宿主: 兔 Polyclonal RB17225 unconjugated
anti-Protein-tyrosine Phosphatase 1C (PTPN6) antibodyPTPN6 适用: 人, 小鼠, 大鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells),Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: A431, A549, PC3, HAP1, HePG2, MCF-7, HeLa, NIH/3T3 and C6 whole cell lysates. Human ovarian carcinoma.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- SHP1 (PTPN6) (Protein-tyrosine Phosphatase 1C (PTPN6))
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别名
- PTPN6
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背景
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APEX1, AP endonuclease class I, AP lyase, APE, APE-1, APEN, APEX nuclease, Redox factor-1, APX, protein REF-1,APEX Nuclease I
Cellular localisation: Mitochondrion. Nucleus. -
分子量
- 35kDa
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基因ID
- 328, 73722
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UniProt
- P27695
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途径
- JAK/STAT Signaling, TCR Signaling, TLR signaling, Nuclear Receptor Transcription Pathway, Positive Regulation of Peptide Hormone Secretion, Steroid Hormone Mediated Signaling Pathway, Response to Growth Hormone Stimulus, Regulation of Leukocyte Mediated Immunity, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, BCR Signaling
抗原
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