NKX3-1 抗体 (AA 92-224)
Quick Overview for NKX3-1 抗体 (AA 92-224) (ABIN6938075)
抗原
See all NKX3-1 抗体适用
宿主
克隆类型
标记
应用范围
克隆位点
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抗原表位
- AA 92-224
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特异性
- NKX3.1 is a prostate specific gene encoding a transcription factor that plays an important role in normal prostate development and carcinogenesis. It is a prostatic tumor suppressor gene located on chromosome 8p21.2, which frequently undergoes a loss of heterozygosity. NKX3.1 expression is highly restricted in prostate epithelial cells and therefore can be used as a diagnostic biomarker for prostate cancer and other metastatic lesions of prostatic origin. Furthermore, NKX3.1 shows better sensitivity than Prostate Specific Antigen (PSA) for identifying metastatic prostatic adenocarcinoma. This suggests that immunohistochemical staining of NKX3.1, along with other prostate-restricted markers, may be valuable for the definitive determination of prostatic origin in poorly differentiated metastatic carcinomas.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant fragment (around aa 92-224) of human NKX3.1 protein (exact sequence is proprietary)
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亚型
- IgG2c kappa
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anti-NK3 Homeobox 1 (NKX3-1) (AA 100-209) antibody
NKX3-1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 1C7 unconjugated
anti-NK3 Homeobox 1 (NKX3-1) antibodyNKX3-1 适用: 人 WB, IHC, ELISA, FACS 宿主: 小鼠 Monoclonal 4H4 unconjugated
anti-NK3 Homeobox 1 (NKX3-1) (AA 92-224) antibodyNKX3-1 适用: 人 IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal NKX3-1-2836 unconjugated
anti-NK3 Homeobox 1 (NKX3-1) (AA 92-224) antibodyNKX3-1 适用: 人 IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal NKX3-1-3350 unconjugated
anti-NK3 Homeobox 1 (NKX3-1) (AA 92-224) antibodyNKX3-1 适用: 人 IHC, ELISA, Coat, StM 宿主: 小鼠 Monoclonal NKX3-1-2576 unconjugated
anti-NK3 Homeobox 1 (NKX3-1) (AA 118-145) antibodyNKX3-1 适用: 人 WB, IHC, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-NK3 Homeobox 1 (NKX3-1) (N-Term) antibodyNKX3-1 适用: 人 WB, IHC, ELISA, IHC (p), IHC (fro) 宿主: 小鼠 Monoclonal 3-9 unconjugated
anti-NK3 Homeobox 1 (NKX3-1) antibodyNKX3-1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-NK3 Homeobox 1 (NKX3-1) (AA 118-145) antibodyNKX3-1 适用: 人 WB, IHC (p), FACS 宿主: 兔 Polyclonal RB23610 unconjugated
anti-NK3 Homeobox 1 (NKX3-1) (AA 100-209) antibodyNKX3-1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3C1 unconjugated
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应用备注
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Known_Application: ELISA (For coating, order Ab without BSA),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Highly expressed in the prostate and at a lower level in the testis.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- NKX3-1 (NK3 Homeobox 1 (NKX3-1))
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别名
- NKX3-1
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背景
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NK3 Homeobox 1, Homeobox Protein NK-3 Homolog A, NKX3-1, NKX3A, NK3 Transcription Factor Related, Locus 1 (Drosophila), NK3 Transcription Factor Related, Locus 1, NK Homeobox (Drosophila), Family 3, A, NK3 Transcription Factor Homolog A, NK Homeobox, Family 3, A, Homeobox Protein Nkx-3.1, BAPX2, NKX3,NKX3.1 (Metastatic Prostate Adenocarcinoma Marker)
Cellular localisation: Nuclear -
分子量
- 35kDa
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基因ID
- 4824, 55999
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UniProt
- Q99801
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途径
- Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Endopeptidase Activity, Positive Regulation of Response to DNA Damage Stimulus
抗原
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